视网膜细胞瘤的研究进展

Research advance ment in retinocytoma

视网膜细胞瘤是发生于视网膜组织的一种良性肿瘤。该病自1982年由Gallie等首次描述，迄今人们对其认识日渐加深。越来越多的临床和组织病理学研究提示，视网膜细胞瘤可能是视网膜母细胞瘤（RB）的早期转化阶段或是RB的一种类型，且由于该病早期无明显的临床症状，因而难以发现。因此认为通过对RB患者的亲属进行随访和筛查，以便早期发现、早期诊断和早期干预视网膜细胞瘤对于防止和阻断其向恶性肿瘤的转化进程具有重要的临床意义。收集国内外关于视网膜细胞瘤的研究和报道，对视网膜细胞瘤的命名变迁、临床表现、病理特征、分子机制研究及遗传学特点等方面进行综述。

Retinocytoma is a benign tumor arising from the retina. Since it was first described by Gallic in 1982,retinocytoma has been progressively recognized. More and more clinical and pathological studies indicate that retinocytoma may be a early stage or a type of retinoblastoma. Retinocytoma is difficult to be found because of lack clinical signs. Therefore,it is very important for us to follow-up and screen the families of RB patient in order to intervene with the course of disease as early as possible for preventing and arresting the malignization of retinocytoma toward RB. The name alteration, clinical manifestations,histopathological features, molecular mechanism and heredity characteristics were reviewed.