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DNA结合分化抑制蛋白1与KI-67和血管内皮生长因子在直肠癌组织中的表达 被引量：5

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摘要 目的探讨DNA结合分化抑制蛋白1（ID-1）在直肠癌中的表达及与KI-67、血管内皮生长因子（VEGF）的关系及其临床意义。方法采用免疫组织化学法检测62例（男38例，女24例）直肠癌组织中ID-1、KI-67、VEGF的表达情况。结果在直肠癌组织中ID-1高表达．KI-67和VEGF表达率也增高（均P〈0．05），三者表达水平均与肿瘤细胞的浸润程度有关。结论ID-1、KI-67和VEGF三者的表达强度均与直肠癌T分期有关．三者的联合检测有助于直肠癌临床分期的判断。
作者 叶英海 张晓勇 周晓聪 刘学文
机构地区 浙江省温州市第二人民医院肿瘤外科 河南省南阳医学高等专科学校第一附属医院普通外科 中山大学附属肿瘤医院腹部外科
出处 《中华胃肠外科杂志》 CAS 北大核心 2011年第7期552-553,共2页 Chinese Journal of Gastrointestinal Surgery
关键词 直肠肿瘤 DNA结合分化抑制蛋白1 KI-67 VEGF
分类号 R735.37 [医药卫生—肿瘤]
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参考文献8

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  • 2Ding R, Hart S, Lu Y, et al. Overexpressed Id-1 is associated with patient prognosis and HBx expression in hepatitis B virus- related hepatocellular carcinoma. Cancer Biol Ther, 2010, 10(3 ) : 56-60.
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二级参考文献21

  • 1刘豫瑞,庄则豪,李友炳,黄雄飞,曾达武.ID-1、Ki-67及Bcl-2在食管鳞状细胞癌中的表达及意义[J].中华消化内镜杂志,2005,22(5):327-330. 被引量：10
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共引文献6

同被引文献52

  • 1史建伟,于跃明,王士杰,王小玲,张娟,王贵英.细丝蛋白A和基质金属蛋白酶9在结直肠腺癌中的表达及意义[J].肿瘤,2010,30(9):768-773. 被引量：11
  • 2Hsieh SH, Ying NW, Wu MH, et al. Galectin-1, a novel ligand of neuropilin-1 activates VEGFR-2 gration of vascular endothelial (26) :3746-3753. signaling and modulates themi- cells [ J ]. Oncogene, 2008, 27.
  • 3Edwards LA, Fine HA. The Ids have it[ J]. Cancer Ce11,2010,18 ( 6 ) : 543 -545.
  • 4Prat J. FIGO staging for uterine sarcoma [ J ]. Int J Gynecl Obstet, 2009.104 (2), 177-179.
  • 5Girardi F, Franeeschi E, Brandes AA. Cardiovascular safety of VEGF-targeting therapies: current evidence and handling strate- gies[ J]. Oneologist ,2010,15 (7) :683-694.
  • 6Maw MK, Fujmoto J, Tamaya T. Overexpression of inhibitor of DNA-binding(Id)-1 protein related to angiogenesis in tumor ad- vancement of ovarian cancers [ J 1. BMC Cancer, 2009,10 ( 9 ) : 430-436.
  • 7Dong Z, Uu S, Zhou C, et al. Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squa- mous cell carcinoma [ J ]. Oral Oncol,2010,46 (3) : 154-157.
  • 8Yu XL, Xu XHU, Han B J, et al. Inhibitor of DNA binding-1 over- expression in prostate cancer: relevance to tumor differentiation [ J ]. Pathol Oneol Res,2009,15 ( 11 ) :91-96.
  • 9Ding R, Han S, Lu Y, et al. Overexpressed Id-1 is associated with patient prognosis and HBx expression in hepatitis B virus-related hepatocellular carcinoma[ J ]. Cancer Biol Ther ,2010,10 (3) :56- 60.
  • 10Edwards LA, Fine HA. The Ids have it[J]. Cancer Cell, 2010, 18:543 - 545.

引证文献5

二级引证文献44

中华胃肠外科杂志
2011年 第7期

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