新疆部分地区维、汉族变应性鼻炎患者HLA-DQB1基因多态性分析

Analysis of HLA-DQB1 polymorphism for patienets with allergic rhinitis of Uygur and Han people in Xinjiang

目的:研究新疆地区维、汉族蒿属花粉变应性鼻炎(AR)患者HLA-DQB1等位基因与蒿属过敏易感性的关系。方法:采用聚合酶链反应-序列特异性引物技术,对新疆地区50例维族和50例汉族蒿属花粉AR患者的HLA-DQB1等位基因进行检测,对照组为本地区的50例维族和50例汉族学生和本院职工。结果:统计分析结果显示维族AR组HLA-DQB1*05等位基因频率19.4%明显高于对照组7%(P<0.05),差异有统计学意义。汉族AR组HLA-DQB1等位基因频率与汉族正常对照组间没有统计学差异。结论:提示HLA-DQB1*05可能是新疆部分地区维族AR发病的易感基因。

Objective：To investigate the association of HLA-DQB1 alleles and artemisia pollen allergic patients of han and uygur people in the Xinjiang area.Method：PCR-SSP（sequence-specific primer polymerase chain reaction） were used to test fifty uygur and fifty han people with allergic rhinitis with hypersensitivity to artemisia pollen in the Xinjiang area.Fifty normal uygur and fifty normal han people in the Xinjiang region were enrolled in the control group.Result：The frequency of HLA-DQB1＊05 in the uygur group with allegic rhinitis was significantly higher（19.4%） than that in the uygur control group（7%）（P0.05）.There were no significant difference between in the allergic rhinitis group and in the control group.Conclusion：HLA-DQB1＊05 might be the susceptibility genes of the uygur patients with allergic rhinitis in the Xinjiang area.