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IL-17^+ γδT细胞 被引量：2

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摘要 IL-17是一种重要的炎症介质,最近研究显示,除了Th17细胞,γδT细胞也能够产生IL-17,并且比αβT细胞产生得更为迅速。与Th17细胞一样,γδT细胞产生IL-17的能力受多种因素影响,并和某些与IL-17相关的疾病有着密切联系,这对相关疾病的致病机制有了新认识,也为这些疾病的治疗提供了新思路。现就近年来对γδT细胞产生IL-17能力的研究,以及这群细胞和疾病的关系进行简要综述。
作者 汤新逸 王胜军
机构地区 江苏大学基础医学与医学技术学院免疫学和免疫检验学系
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2011年第7期817-819,共3页 Chinese Journal of Cellular and Molecular Immunology
基金 国家自然科学基金(30871193 30972748 81072453 30910103087) 江苏省教育厅自然科学基金(08KJB320002) 江苏省卫生厅医学科研基金(200952) 江苏大学"拔尖人才工程"和高级人才基金项目(2008-018-02)
关键词 ΓΔT细胞 IL-17 感染 自身免疫性疾病 肿瘤
分类号 R392.11 [医药卫生—免疫学]
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参考文献19

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  • 21-Iarrington LE, Hatton RD, Mangan PR, et al. Interleukin 17 produ- cing CD4 + effector T ceils develop via a lineage distinct from the T helper type 1 and 2 lineages[ J]. Nat Immunol, 2005, 6(11 ) : 1123 - 1132.
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同被引文献35

  • 1陈勇,李柏青.人γδT细胞TCR分子与结核杆菌多肽抗原特异性结合的证据[J].中华微生物学和免疫学杂志,2005,25(1):15-20. 被引量：20
  • 2Ye Y, Yue M, Jin X, et al. Isolation of murine small intestinal in-traepithelial gammadeltat cells[ J] . Immunol Invest, 2010,39(7 ):661 -673.
  • 3Andreu-Ballester JC, Garcia-Ballesteros C,Benet-Campos C, et al.Values for alphabeta and gammadelta T-lymphocytes and CD4 +,CD8 + , and CD56 + subsets in healthy adult subjects : assessment byage and gender[ J]. Cytometry B Clin Cytom, 2012,82(4) : 238 -244.
  • 4Saito K, Katsuragi H, Mikami M, et al. Increase of heat-shockprotein and induction of gamma/delta T cells in peritoneal exudate ofmice after injection of live Fusobacterium nucleatum[J]. lmmunol(^y,1997,90(2): 229 -235.
  • 5van den Brule S, Heymans J, Havaux X, et al. Profibrotic effect ofIL-9 overexpression in a model of airway remodeling [ J ]. Am JRespir Cell Mol Biol, 2007, 37(2) : 202 - 209.
  • 6Stark MA, Huo Y, Burcin TL, et al. Phagocytosis of 叩optoticneutrophils regulates granulopoiesis via IL-23 and IL-17[J]. Immunity,2005,22(3): 285 -294.
  • 7Blumerman SL,Herzig CT,Baldwin CL. WC1 + gammadelta T cellmemory population is induced by killed bacterial vaccine[ J] . Eur JImmunol, 2007,37(5) : 1204-1216.
  • 8Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-prtMucing CD4 + effector T cells develop v/a a lineage distinct from the T helper type 1 and 2 lineages [ J]. Nat lmmunol, 2005, 6 ( 11 ): 1123 - 1132.
  • 9Lockhart E, Green AM, Flynn JL. IL-17 production is dominated by gammadeha T ceils rather than CD4 T cells during Mycobacterium tuberculosis infection [ J ]. J Immunol, 2006, 177 ( 7 ): 4662- 4669.
  • 10Roar CL, Sinranian PL, Fontenot AP, et al. 18 T cells: an important souree of IL-17[J]. Cur Opin Inmmnol, 2008, 20(3) : 353 -357.

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细胞与分子免疫学杂志
2011年 第7期

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