神龙液合并化疗、放射治疗晚期鼻咽癌

Treatment of advanced nasopharyngeal carcinoma (NPC)by using Shenlongye in combination with chemotherapy and radiotherapy

目的观察神龙液合并化疗、放射治疗晚期鼻咽癌的疗效及毒副反应。方法从1991年3月至1997年2月，对70例晚期鼻咽癌患者进行随机对照研究，35例采用神龙液加化疗并放射治疗（三联组），35例采用单纯放射治疗（对照组）。结果治疗结束时，颈淋巴结消退率三联组为71．43％，对照组为45．71％（P＜0．05），2年生存率三联组为83．53％，对照组为59．23％（P＜0．05）。结论研究提示中西医结合治疗晚期鼻咽癌是可取的，神龙液可增加肿瘤对放化疗敏感性及降低放化疗的毒副作用，不增加血行转移。

To assess the efficacy and side effect of using Shenlongye in combina tion with chemotherapy and radiotherapy in treating advanced nasopharyngeal carcinoma. Methods From March 1991 to February 1997, 70 patients with advaneed NPC were randomly divided into two groups: 35 patients were treated by combined therapy of Shenlongye-Chemotherapy-Radiothe (Triple group ), and other 35 by radiotherapy aloneas control group, the clinical conditions of the both groups were similar before treatment;and the methods and doses of irradiation in both groups were same. ResuIts At the end of treatment, the immediate regression rate of cervical lymph nodes of trip1e group and control group were 71. 43 % and 45. 71 % respectively in comparison of two groups, the difference was significant (P<0. 05),the 2-year survival rate in the triple group was 83. 53% and 59. 23% in control group(P<0. 05). Conclusion This study implies that Chinese herbs in combina tion with chemotherapy and radiotherapy for advaneed NPC was preferable in increasing the sensitivi ty of tumor to chemo-radiotherapy,reducing their side-effect and prevent the hematogenous metastasis.