摘要
目的探讨山东汉族人群2型糖尿病与5-羟色胺转运体启动子区基因多态性(5-HTTLPR)的关系。方法选取387例2型糖尿病患者和286例对照个体,采用聚合酶链反应(PCR)技术检测5-HTTLPR多态性。结果Ls基因型和ss基凶型在病例组所占比例(74.2%)明显高于对照组(62.9%)(P〈0.01),5-HTTLPR等位基因频率分布两组之间差异具有统计学意义(P〈0.05);S等位基因明显增加患2型糖尿病的遗传风险性(OR=1.73,95%可信区间1.24~2.43,P〈0.01)。结论5-HTTLPR基因多态性可能与2型糖尿病相关。
Objective To investigate the relationship between the serotonin transporter promoter polymorphism (5 - HTTLPR) and type 2 diabetes mellitus in the Chinese Han population from Shandong province. Methods The study selected 387 subjects diagnosed with type 2 diabetes mellitus and 286 non - diabetic subjects. The PCR technology was used to examine the 5 - HTTLPR polymorphism. Results The frequency of LS and SS genotypes of the 5 - HTTLPR was significantly higher in the cases (74.2%) than in the controls (62.9%) (P 〈0.01 ). And significant difference was found in the frequency of allele of 5 -HTTLPR between the cases and the controls (P 〈 0.05). The S allele significantly increased the genetic risk of type 2 diabetes mellitus compared to the controls( OR = 1.73,95% CI = 1.24 - 2.43, P 〈 0. 01 ). Conclusion The 5 - HTTLPR gene polymorphism might be associated with type 2 diabetes mellitus.
出处
《医学研究杂志》
2011年第7期88-90,共3页
Journal of Medical Research