5-HTTLPR基因多态性与2型糖尿病关联性研究

Relationship between the Serotonin Transporter Promoter Polymorphism(5-HTTLPR) and Type 2 Diabetes Mellitus

目的探讨山东汉族人群2型糖尿病与5-羟色胺转运体启动子区基因多态性（5-HTTLPR）的关系。方法选取387例2型糖尿病患者和286例对照个体，采用聚合酶链反应（PCR）技术检测5-HTTLPR多态性。结果Ls基因型和ss基凶型在病例组所占比例（74．2％）明显高于对照组（62．9％）（P〈0．01），5-HTTLPR等位基因频率分布两组之间差异具有统计学意义（P〈0．05）；S等位基因明显增加患2型糖尿病的遗传风险性（OR=1．73，95％可信区间1．24～2．43，P〈0．01）。结论5-HTTLPR基因多态性可能与2型糖尿病相关。

Objective To investigate the relationship between the serotonin transporter promoter polymorphism （5 - HTTLPR） and type 2 diabetes mellitus in the Chinese Han population from Shandong province. Methods The study selected 387 subjects diagnosed with type 2 diabetes mellitus and 286 non - diabetic subjects. The PCR technology was used to examine the 5 - HTTLPR polymorphism. Results The frequency of LS and SS genotypes of the 5 - HTTLPR was significantly higher in the cases （74.2%） than in the controls （62.9%） （P 〈0.01 ）. And significant difference was found in the frequency of allele of 5 -HTTLPR between the cases and the controls （P 〈 0.05）. The S allele significantly increased the genetic risk of type 2 diabetes mellitus compared to the controls（ OR = 1.73,95% CI = 1.24 - 2.43, P 〈 0. 01 ）. Conclusion The 5 - HTTLPR gene polymorphism might be associated with type 2 diabetes mellitus.