肝癌肝移植术后肿瘤复发转移的防治

Tumor recurrence after liver transplantation for hepatocellular carcinoma： prevention and treatment

肝癌肝移植术后肿瘤复发转移是影响肝移植治疗肝癌疗效的主要因素。深入研究肝癌的生物学特性和肝移植术后患者免疫状态与肿瘤复发转移的关系，筛选准确预测肝癌肝移植的预后指标，对高危复发风险的患者进行有效的干预治疗，对复发转移者进行个体化综合治疗有助于进一步提高肝移植治疗肝癌的疗效。

Post-transplant tumor recurrence and me- tastasis remain the main obstacles for long-term survival af- ter liver transplantation （LT） for hepatocellular carcinoma （HCC）. Measures to explore the HCC biological character- istics and the relationship between post-transplant immuno- suppression and tumor recurrence, to determine precisely the prognostic factors associated with post-transplant recur- rence, to intervene effectively for those with high risk of recurrence, and to use individualized multimodality treatment for recurrence and metastasis may improve the therapeutic results of LT for HCC.