胆管癌的危险因素及相关病理机制

Cholangiocarcinoma： risk factor and related pathomechanism

胆管癌早期诊断困难、恶性程度高。其发生发展涉及很多危险因素，但导致胆管细胞癌变的共同通路是慢性炎症和胆汁淤积两个基础性病理过程。本文以胆管癌的危险因素和相应的病理机制为切人点，就与之相关的胆管癌分子生物学特性做一综述。

Cholangiocarcinoma is rare. It is highly malignant and early diagnosis is difficult. Various risk facts have been linked to the carcinogenesis and development of cholangiocarcinoma. Chronic inflammation and cholestasis are the two common pathways in the malignant transforma- tion of cholangial cells. We reviewed the molecular biological researches of cholangiocarcinoma from two aspects： its risk factors and related pathomechanism.