润肠通乐口服液对习惯性便秘小鼠通便作用的实验研究

Experimental Study About Laxative Effect of Oral Runchang Tongle Liquid on Habitual Constripation Mice

目的观察润肠通乐口服液对习惯性便秘小鼠的通便作用。方法采用隔日饮食与过度疲劳结合缺水燥结法复制便秘模型,观察润肠通乐口服液对便秘小鼠首次排便粒数、脏器系数、游泳时间的影响。结果润肠通乐口服液大、中剂量能使小鼠排便粒数明显增多(p<0.05);能明显提高小鼠游泳时间(P<0.05);对小鼠肝、脾、肾、胸腺系数较模型有明显提高(P<0.05)。结论本研究对润肠通乐口服液治疗习惯性便秘提供了实验依据。

Objective Observing laxative effect of Oral Runchang Tongle Liquid on habitual constripation mice. Methods Using the way which is associated with every other day diet, immoderate fatigue and water depletion to copy the constipation model. Through taking Oral Runchang Tongle Liquid, observing the results about the first time mice the total amount of defecation, organ coefficient, swimming time. Results Oral Runchang Tongle Liquid large dose and moderate dose can significantly increase the the total amount of defecation; Oral Runchang Tongle Liquid large dose and moderate dose also can improved swimming time（P〈0.05） ;Compared with model mice, large and moderate dose mice＇s sliver, spleen, kidney, thymus coefficient have uncommonly-improve（P〈0.05）.Conclusion From defecation amount, swimming time, organ coefficient we can see Oral Runchang Tongle Liquid have favorable effect on habitual constripation mice.