高血压患者颈动脉内膜-中膜厚度与血压、血脂、血糖和高敏C反应蛋白的关系

The Relationships of Carotid Intima-media Thickness and Dyslipidemia,Hyperglycemia and Hypersensitive C-reactive Protein in Hypertensive Patients

目的:研究高血压患者颈动脉内膜-中膜厚度(IMT)与血脂、血糖以及高敏C反应蛋白(hsCRP)的关系。方法:110例高血压患者分为IMT正常组、IMT增厚组及斑块组,测定其血压和血清甘油三酯(TG),总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C),高密度脂蛋白胆固醇(HDL-C),hsCRP,空腹葡萄糖(FPG)和餐后2小时葡萄糖(2hPG)水平。结果:高血压患者的颈动脉病变越重,伴有高血糖和血脂异常的比例越高,与IMT正常组相比,IMT增厚组和斑块组的TC、LDL-C和hsCRP增高,具有统计学差异;SBP、TG、FPG、2hPG增高在斑块组具有统计学差异,在IMT增厚组无统计学差异。斑块组SBP、LDL-C、FPG、2hPG和hsCRP较IMT增厚组升高,有统计学差异。颈动脉IMT与SBP、TC、LDL-C、FPG、2hPG和hsCRP相关。结论:SBP、TC、LDL-C、FPG、2hPG和hsCRP等心血管危险因素与高血压患者颈动脉IMT有关。

Objective： To investigate the relationships of carotid intima-media thickness （IMT） and dyslipidemia, hyperglycemia and hypersensitive C-reactive proteift （hsCRP） in patients with hypertension. Methods： 110 patients with essential hypertensive were divided into 3 groups according to carotid IMT, IMT normal group, IMT increased group and plaque group. Carotid IMT, systolic blood pressure （SBP）, diastolic blood pressure（DBP）, serum total glycerin （TG）, total cholesterol （TC）, low-dense-lipoprotein cholesterol （LDL-C）, high-dense-lipoprotein cholesterol （HDL-C）, hypersensitive C-reactive protein （hsCRP）, fast plasma glucose （FPG） and 2h plasma glucose （2hPG） were measured. Results： Compared to IMT normal group, The level of TC,LDL-C and hsCRP in IMT increased group and plaque group were increased significantly. SBP, TG, FPG and 2hPG were increased significantly in plaque group. Compared to IMT increased group, SBP, LDL-C, FPG, 2hPG r~ hsCRP in plaque group were increased significantly. Conclusion： Carotid IMT is related to SBP, TC, LDL-C, FPG, 2hPGand hsCRP.