3项血清指标与妊娠期高血压疾病患者的相关性研究

Research on the relationship between patients with hypertensive disorders in pregnancy and three serum indicators

目的探讨同型半胱氨酸(Hcy)、血管紧张素Ⅱ(AngⅡ)、超敏C-反应蛋白(hs-CRP)的水平与妊娠期高血压疾病(HDP)患者、健康晚孕期妇女及健康未怀孕妇女的关系。方法选择HDP患者70例,其中妊娠期高血压34例,子痫前期轻度22例,子痫前期重度14例;并随机选取同期健康晚期孕妇35例,健康非孕妇30例作对照。检测其血清Hcy、hs-CRP、AngⅡ的水平。结果 (1)与健康晚孕期妇女及健康未孕期妇女相比,妊娠期高血压、轻度子痫前期和重度子痫前期组Hcy、AngⅡ、hs-CRP的水平均明显增高,差异有统计学意义(P<0.01);(2)重度子痫前期和轻度子痫前期相比Hcy、AngⅡ、hs-CRP的水平均明显增高,差异有统计学意义(P<0.01);(3)轻度子痫前期和妊娠期高血压相比Hcy、AngⅡ、hs-CRP的水平均明显增高,差异有统计学意义(P<0.01);(4)Hcy与AngⅡ、hs-CRP呈明显正相关。结论 Hcy、AngⅡ和hs-CRP水平与HDP的发生、发展有关,且Hcy与AngⅡ、hs-CRP呈明显正相关。

Objective To explore the relationships among the levels of Hcy,Ang Ⅱ,hs-CRP and patients with hypertensive disorders of pregnancy（HDP）,health late pregnancy women,non-pregnancy women.Methods 70 patients with HDP were chosen.Among them,there were 34 patients with HDP,22 with mild pre-eclampsia,14 with serious pre-eclampsia.For comparison,35 health late pregnancy women and 30 non-pregnancy women were chosen randomly in the same period.Results（1） The levels of Hcy,Ang Ⅱ,hs-CRP in patients with HDP,mild pre-eclampsia,serious pre-eclampsia were higher than those of health late pregnancy women and non-pregnancy women,with significant difference（P0.01）.（2） The levels of Hcy,Ang Ⅱ,hs-CRP in patients with serious pre-eclampsia were higher than those of patients with mild pre-eclampsia,with significant difference（P0.01）.（3） The levels of Hcy,Ang Ⅱ,hs-CRP in patients with mild pre-eclampsia were higher than those of patients with HDP,with significant difference（P0.01）.（4） The level of Hcy was positively related to the levels of Ang Ⅱ and hs-CRP.Conclusion The levels of Hcy,Ang Ⅱ,hs-CRP of patients are associated with the occurrence and the development of HDP.And the level of Hcy is positively related to the levels of Ang Ⅱ and hs-CRP.