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低分子量肝素对阿霉素肾病大鼠的抗凝作用

The anticoagulative effect of low-molecular-weight heparin on rats with adriamycin nephropathy
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摘要 目的 观察低分子量肝素(LMWH) 对阿霉素(soxorubicim)肾病大鼠的抗凝作用。方法 采用阿霉素复制肾病综合征模型大鼠,并随机分为4 组,以0-9% NaCl 注射液为对照组,以不同剂量的低分子量肝素为观察组Ⅰ,Ⅱ,Ⅲ。结果 观察各组的凝血因子Ⅹ、凝血因子Ⅱ的活性明显低于对照组( P<0-05) ,观察组Ⅲ与观察组Ⅰ比较差异也有显著性(P<0-05),观察各组的肝素辅因子Ⅰ明显低于对照组( P< 0-05) ;观察各组的蛋白S明显高于对照组( P< 0-05)。结论 低分子量肝素能改善肾病综合征的高凝状态,且抗凝作用与剂量成正相关。 Objective To investigate the articoagulative effect of LMWH on rats with ADR nephropathy. Methods Rats were injected with ADR intraverously to establish nephrotic syndrome modle and were divided into 4 groups. Group Ⅰ,Ⅱ and Ⅲ were given LMWH of various doses for one month. The remaining group was as controls. Results Plasma factors X, factors Ⅱ and AT-Ⅲ in group Ⅰ,Ⅱ and Ⅲ were significantly lower than those in controls ( P <0 05). Plasma protein S in group Ⅰ, Ⅱ and Ⅲ was significantly higher than that in controls ( P <0 05). Conclusion LMWH can attenuate hypercoagulability of nephrotic syndrome in a dose-dependent manner.
出处 《广东医学》 CAS CSCD 1999年第12期921-922,共2页 Guangdong Medical Journal
关键词 肾病综合征 低分子量肝素 阿霉素 抗凝作用 Nephrotic syndrome Low molecular-weight heparin Rat
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参考文献3

  • 1尤蓓.低分子量肝素与心血管疾病[J].国外医学(心血管疾病分册),1997,24(5):19-22. 被引量:115
  • 2尤蓓,国外医学心血管疾病分册,1997年,24卷,19页
  • 3王振义,血栓与止血基础理论与临床(第2版),1996年,396页

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