低分子量肝素对阿霉素肾病大鼠的抗凝作用

The anticoagulative effect of low-molecular-weight heparin on rats with adriamycin nephropathy

目的 观察低分子量肝素（ＬＭＷＨ） 对阿霉素（ｓｏｘｏｒｕｂｉｃｉｍ）肾病大鼠的抗凝作用。方法 采用阿霉素复制肾病综合征模型大鼠，并随机分为４ 组，以０－９％ ＮａＣｌ 注射液为对照组，以不同剂量的低分子量肝素为观察组Ⅰ，Ⅱ，Ⅲ。结果 观察各组的凝血因子Ⅹ、凝血因子Ⅱ的活性明显低于对照组（ Ｐ＜０－０５） ，观察组Ⅲ与观察组Ⅰ比较差异也有显著性（Ｐ＜０－０５），观察各组的肝素辅因子Ⅰ明显低于对照组（ Ｐ＜ ０－０５） ；观察各组的蛋白Ｓ明显高于对照组（ Ｐ＜ ０－０５）。结论 低分子量肝素能改善肾病综合征的高凝状态，且抗凝作用与剂量成正相关。

Objective To investigate the articoagulative effect of LMWH on rats with ADR nephropathy. Methods Rats were injected with ADR intraverously to establish nephrotic syndrome modle and were divided into 4 groups. Group Ⅰ,Ⅱ and Ⅲ were given LMWH of various doses for one month. The remaining group was as controls. Results Plasma factors X, factors Ⅱ and AT-Ⅲ in group Ⅰ,Ⅱ and Ⅲ were significantly lower than those in controls ( P <0 05). Plasma protein S in group Ⅰ, Ⅱ and Ⅲ was significantly higher than that in controls ( P <0 05). Conclusion LMWH can attenuate hypercoagulability of nephrotic syndrome in a dose-dependent manner.