恬尔心静脉注射液治疗原发性高血压病临床观察

CLINICAL OBSERVATION OF DILTIAZEN HYDROCHLORIDE INJECTION IN THETREATMENT OF PRIMARY HYPERTENSION

目的：为观察钙离子拮抗剂恬尔心针剂静脉推注治疗原发性高血压临床降压效果及对心率影响。方法：已确诊的原发性高血压病患者４０ 例、在自动测压心电监护仪血压监测下，静脉注射恬尔心针剂，剂量按体重０．２～０．３ｍ ｇ／ｋｇ 计算，稀释于２５％ 葡萄糖液２０ｍ ｌ内，３ｍ ｉｎ 推注完毕，记录即刻、５、１０、２０、３０ｍ ｉｎ 血压、心律和Ｐ—Ｒ 间期变化。将静注后即刻至３０ｍ ｉｎ 听测得５ 次数值的均数与用药前测得的均数采用自身对照ｔ检验进行统计学处理。结果：４０ 例观察对象平均体重６４．２ｋｇ，平均恬尔心静注剂量１２．８４～１９．２６ｍ ｇ。取得降压效果显效２５ 例，显效率６２．５％ （２５／４０），有效４０ 例，有效率１００％ （４０／４０），注射后３６ 例心律减慢，由用药前９０．２８±２５．７５ 次／ｍ ｉｎ 下降３０ｍ ｉｎ 后的７８．０８±１１．７８ 次／ｍ ｉｎ，（Ｐ＜ ０．００１）。本组未见明显不良反应。结论：静脉注射恬尔心针剂治疗高血压急症，降压效果迅速、确切，用药安全，值得临床推广。

Objective:To observe the effect of hypotension and the influence of HR of Diltiazen Hydrochloride injection(calcium antagonist)in treating primary hypertension Methods:40 cases of primary hypertension confirmed diagnosis were given intravenous therapy(0.2～0.3mg/kg+25%G.S.20ml,finished treatment in 3minutes under automatic blood pressuer monitor.We recorded the change of BP,HR and P-R space immediately and after 5,10,20 and 30 minutes.The mean of five date from immediate to 30 minutes later and the mean before treatment were auto controled and statistically managed by T test.Result:The average body weight ,the average dosage of Dilitazen Hydrochloride injection was 64.2kg,12.84～19.26mg respectively.25 cases had significant effectiveness.The significant effective rate was 62.5%(25/40).All 40 cases had effectiveness.So the effective rate was 100%(40/40).36 casess HR reduced from 90.28±25.75 times/min before treatment to 78.08±11.78 times/min 30 minutes later(P<0 0001) And it had no distinct ill effect.Conclusion:Dilitazem hydrochloride injection had quickly and definite effect in the treating hypertension cmergeney.And it was safe and worthy of clinical service.