辅助生殖技术与基因印迹异常

Assisted Reproductive Technology and Abnormalities in Genomic Imprinting

基因印迹指某些基因来源于不同亲代的一对等位基因发生的差异性表达。关于辅助生殖技术(ART)与基因印迹异常的相关研究已成为生殖安全研究的前沿和热点。ART包括控制性超排卵、体外受精/胞浆内单精子注射、胚胎体外成熟和胚胎移植等,而究竟哪个环节造成、如何造成基因印迹异常,乃至引起基因印迹疾病目前尚未明确。诸多研究显示,在患者不孕不育背景的影响下,超排卵、卵子体外成熟、体外受精和胚胎操作都从不同角度、以不同程度造成基因印迹异常。

Genomic imprinting means the differential expression of allele genes which derivatived from either parents.The relationship between assisted reproductive technology（ART） and abnormalities in genomic imprinting needs further study in the field of fertility safety.ART comprises several steps,including the controlled ovarian stimulation（COS）,in vitro fertilization（IVF）/intra-cytoplasmic single sperm injection（ICSI）,in vitro maturation（IVM）,embryo transfer（ET）,etc.It is not clear which step of ART and how to give rise to abnormalities in genomic imprinting.On the basis of infertility,COS,IVM,IVF/ICSI and embryo manipulation could lead to abnormalities in genomic imprinting to varying degrees,from a different perspective.