玳玳果黄酮滴丸对高脂血症大鼠的降血脂作用研究

Study on Antiatheroscloresis Effects of Daidai Flavones Dropping Pills on Hyperlipidemia Rats

目的建立大鼠高血脂模型,观察玳玳果黄酮滴丸对高脂血症大鼠的降血脂作用。方法选用SD大鼠60只,♂,10只作为空白对照组,喂饲普通饲料,其余高脂饲料喂饲,建立高脂血症模型,测定用药前后血清中胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)的含量;同时取肝脏切片,HE染色,观察玳玳果黄酮滴丸的降血脂作用。结果玳玳果黄酮滴丸各剂量组均能明显降低高血脂大鼠血清中TC、TG和LDL-C含量;能明显升高大鼠血清中HDL-C含量。病理切片结果显示,玳玳果黄酮滴丸能够明显减轻肝脏的脂肪变性。结论玳玳果黄酮滴丸对大鼠高脂血症有明显的预防作用,并能够阻止高脂血症大鼠的肝脏脂肪变性。

OBJECTIVE Establish the hyperlipidemia rats model to observe antiatheroscloresis effects of daidai flavones dropping pills on hyperlipidemia rat. METHODS Sixty SD rats were grouped randomly. Among them, 10 were in control group, fed with conventional forage, while others were fed with high fatty forage, establish the hypedipidemia model. The content of cholesterol （TC）, triglycerides （TG）, low-density lipoprotein （LDL-C） and high-density lipoprotein （HDL-C） in serum were determined. Tak~ the liver, HE dyeing, to study the role of the daidai flavones dropping pills on lower cholesterol in hyperlipidemia rats. R1ESULTS The dropping pills could significantly lower the high blood fat rats＇ serum TC, TG and LDL-C content, could obviously increase the rats＇ serum HDL-C content. Furthermore, fatty degeneration was eased by daidai flavones dropping pills according to the pathological result. CONCLUSION The daidai flavones dropping pills have good precautionary and therapeutic effect on hyperlipemia rats, which can prevent fatty degeneration among rats.