热熔制粒在口服固体制剂中的应用

Application of Hot Melt Granulation in Oral Solid Dosage Forms

目前,多种不同的热熔制粒方法在颗粒剂、片剂、胶囊剂等口服固体制剂的制备中得以应用。本文综述了热熔制粒法的特点、设备、黏合剂、应用、发展趋势、产业化的关键问题及解决途径,重点介绍了具有不同溶解性、起关键作用的低熔点黏合剂。

In recent times, various methods of hot melt granulation have been adopted in the preparation of oral solid dosage forms, such as granules, tablets and capsules. This paper presents a review of these methods＇ features, equipments, binders, applications, tendencies, problems and solutions of industrial production. Special emphasis is put on binders with low melt point and different solubility, which olay crucial roles in hot melt granulation.