刮筋板化学成分研究

Chemical constituents of Excoecaria acerifclia

目的:对刮筋板化学成分进行分离和鉴定。方法:采用硅胶柱色谱、Sephadex LH-20柱色谱等方法进行成分分离及纯化,并利用1H-NMR,13C-NMR,MS等波谱技术鉴定其化学结构。结果与结论:从刮筋板全草70%丙酮水提取液的醋酸乙酯部分分离得到14个单体化合物,分别鉴定为7,8-trans-4,5,9-trihydroxy-3,3′,9′-trimethoxy-7-O-5′,8-O-4′-neolignan(1),7,8-trans-4,5,9,9′-tetrahydroxy-3,3′-dimethoxy-7-O-5′,8-O-4′-neolignan(2),malloapelin C(3),syringaresinol(4),2α,3β,24-trihydrox-y-12-ursen-28-oic acid(5),11-hydroxy-3-oxo-12-ursen-28-oic acid(6),6-hydroxy-20(29)-lupen-3-one(7),isolupenyl acetate(8),kaempferol(9),quercetin(10),apigenin(11),catechin(12),kamepferol-3-O-β-D-galactopyranoside(13),catechin(6→8)catechin(14)。结论:化合物1为新化合物,化合物2～14为首次从该植物中分离得到。其中化合物5～8为三萜类化合物,其他化合物为苯丙素类化合物。

Objective： To study the chemical constituents of Excoecaria acerifclia. Method： Column chromatography on Silica gel and Sephadex LH-20 were applied for isolation and purification of the constituents. The structures were elucidated on the basis of spectrascopic analysis, chemical evidences and by comparison with the data reported in the literature. Result： From the crude EtOAc fraction of Excoecaria acerifclia F. Didr, 14 compounds were isolated and identified as 7,8-trans-4,5,9-trihydroxy-3,3＇,9＇-trimethoxy-7-O-5＇,8-O-4＇-neolignan （1）, 7,8-trans -4,5,9,9＇-tetrahydroxy-3,3＇-dimethoxy-7-O-5＇,8-O-4＇-neolignan （2）, malloapelin C （3）, syringaresinol （4）, 2α,3β,24-trihydroxy-12-ursen-28-oic acid （5）, 11-hydroxy-3-oxo-12-ursen-28-oic acid （6）, 6-hydroxy-20（29）-lupen-3-one （7）, isolupenyl acetate （8）, kaempferol （9）, quercetin （10）, apigenin （11）, catechin （12）, kamepferol-3-O-β-D-galactopyranoside （13）, and catechin（6→8） catechin （14）. Conclusions：Compound 1 was new, the remained compounds were isolated and identified from E. acerifclia for the first time. Among them, compounds 5-8 are triterpenoids, while the other compounds are phenylpropanoids.