茯苓三萜成分及其衍生物的构效关系研究

Studies on the Derivatives and Structure Activity Relationships of Fuling Triterpene

从国产茯苓中分离出3 种茯苓三萜成分,制备了14 个茯苓三萜衍生物,其化学结构经元素分析、质谱、红外、紫外和核磁共振等确证无误.同时测定了它们对小鼠肝癌H22 细胞的抑制率,并对其构效关系进行了初步推断.

In search of antitumor structure activity relationships of fuling triterpene and its derivatives and looking for more effective antitumor compounds,we designed and prepared fourteen derivatives of fuling triterpene in this paper.The structures of these new compounds were examined by IR,UV,Mass and 1H NMR spectra as well as elemental analysis.Results of antitumor activity to tumor cell H 22 showed∶The antitumor activity of the ester derivatives was increased,but antitumor activity of the ester derivatives had Cl and Br decreased.