加速溶剂萃取-GC-MS/MS法测定食品接触材料中双酚A、双酚F及其衍生物的残留量

Determination of Bisphenol A,Bisphenol F and Their Derivatives Residues in Food Contact Materials by Accelerated Solvent Extraction and GC-MS/MS

建立了加速溶剂萃取-气相相色谱-串联质谱法测定食品接触材料(婴儿奶瓶)中双酚A、双酚F及其衍生物残留量的分析方法。样品用二氯甲烷作提取剂,用加速溶剂萃取仪进行了提取,经乙酸酐衍生化,用气相色谱-串联质谱仪进行了定性、定量分析。结果表明:BPA,BPF,BADGE,BFDG 4种化合物的回收率范围在78.9%～101.1%之间,相对标准偏差小于10%,线性关系良好,方法的检出限分别为0.2,0.1,5,5 ng/g,该方法简便、快速、灵敏度高、重复性好。

An accelerated solvent extraction followed by gas chromatography-tandem mass spectrometry was developed for determination of bisphenol A,bisphenol F and their derivatives residuals in food contact materials.Samples were extracted with dichloromethane in an accelerated solvent extractor,and derivatized by a commercial acetic anhydride prior to GC-MS/MS analysis.The results showed that the recovery of BPA,BPF,BFDGE and BADGE was in the range of 78.9%～101.1%,with the relative standard deviation（RSD） value less than 10%;the linearity is good（R20.995）;the detection limits are 0.2,0.1,5,and 5 ng/g respectively.It was concluded that the method is simple,fast,sensitive,and of good repeatability.