细胞周期蛋白依赖性激酶抑制剂的临床研究进展

Progress in clinical trails of cyclin dependent kinase inhibitors

细胞周期是细胞生命活动的重要环节,细胞周期调控的失调与细胞癌变密切相关。细胞周期蛋白依赖性激酶(cyclin-dependent kinases,CDK)可促进细胞周期有序进行,因而细胞周期蛋白依赖性激酶抑制剂(cyclin-dependent kinases inhibitor,CDKI)可以阻断细胞周期,控制细胞增殖从而具有抗肿瘤活性。本文综述了近年来CDKI的研究进展,重点介绍了近年来对一些CDKI进行的临床前或临床研究,并展望了CDKI的的发展方向。

Cell cycle is a key step of a cell life,and the disorder of cell cycle can lead to the canceration.It is well known that cyclin-dependent kinases（CDK） inhibitors possess the anticancer activities due to their ability of interrupting cell cycle and regulating proliferation of cancer cells.This review summarized the recent progress of cyclin-dependent kinases inhibitors,especially focused on the compounds in preclinical or clinical trails.