SCC-Ag和TK1在中晚期宫颈癌中的表达及在治疗中的意义

Expression of SCC-Ag and TK1 in locally advanced cervical carcinoma and the significance in treatment

目的:探讨SCC-Ag及TK1与中晚期宫颈鳞癌的表达及在治疗中的意义。方法:采集45例中晚期宫颈鳞癌患者在同步化放疗前后的血清标本,所有血清标本进行SCC-Ag及TK1的联合检测。结果:SCC-Ag的阳性率为68.89%,与临床分期,肿瘤大小,淋巴结转移有关(P<0.05),与病理分级无明显相关性(P>0.05)。TK1的阳性率为51.11%,与肿瘤大小,淋巴结转移,病理分级有关(P<0.05),与临床分期无明显相关性(P>0.05)。同步化放疗前SCC-Ag和TK1的浓度分别为(18.92±4.43)ng.mL-1和(12.53±9.46)pmol.L-1,治疗后为(3.51±0.92)ng.mL-1和(1.84±0.45)pmol.L-1,与治疗前相比有显著性差异(P<0.05)。治疗有效与治疗无效组SCC-Ag和TK1浓度变化相比有显著性差异(P<0.05)。治疗前血清SCC-Ag的表达与TK1的表达无明显相关性(P<0.05)。结论:SCC-Ag与TK1能够正确地评价中晚期宫颈癌的治疗疗效,判断肿瘤预后。

Objective： To investigate the expression of SCC-Ag and TK1 in locally advanced cervical carcinoma and the significance in treatment.Methods： Serum samples were collected from 45 patients with locally advanced cervical carcinoma before and after treatment.Levels of SCC-Ag and TK1 were measured.Results： Positive rate of SCC-Ag was 68.89%.The expression of SCC-Ag was significantly associated with clinical stages,lymph node metastasis,and diameter of tumor（P0.05）,but not with histological grade（P0.05）.The positive rate of TK1 was 51.11%.The expression of TK1 was significantly associated with diameter of tumor,lymph node metastasis and histological grade（P0.05）,but not with clinical stages（P0.05）.The levels of SCC-Ag and TK1 were（18.92±4.43） ng·mL-1 and（12.53±9.46） pmol·L-1 before treatment,which were significantly reduced after treatment（3.51±0.92） ng·mL-1 and（1.84±0.45） pmol·L-1,P0.05）.There were significant differences of the levels of SCC-Ag and TK1 between patients with effective and ineffective treatment（P0.05）.The expression of SCC-Ag was not significantly correlated with TK1 in locally advanced cervical carcinoma.Conclusion： SCC-Ag and TK1 can be used for evaluating the effects of treatment and the prognosis in patients with locally advanced cervical carcinoma.