右佐匹克隆治疗失眠症的疗效

Efficacy of dexzopiclone in the treatment of insomnia

目的：观察右佐匹克隆治疗失眠症的临床疗效与不良反应。方法：140例失眠症患者随机分为治疗组（70）例和对照组（70）例。治疗组患者每晚睡前服用右佐匹克隆3~6 mg;对照组患者每晚睡前服用劳拉西泮1~2 mg。连续服用4周。在服药前、服药后1周末、第2周末、第4周末应用＂阿森斯失眠量表（ASDR）＂评定患者睡眠障碍的改善情况。应用＂副反应量表（TESS）＂评定药物的不良反应。结果：ASDR评分在治疗结束时,两组较基线均显著降低（P〈0.01）;研究组和对照组的有效率分别为81.4%和78.6%,两组比较无显著性差异（P〉0.05）。但研究组患者的起效时间较对照组快,总的睡眠质量更好。研究组不良反应发生率低于对照组（P〈0.01）。结论：右佐匹克隆治疗失眠症患者疗效好,且不良反应少,是一种治疗失眠症安全而有效的新药。

Objective： To evaluate the efficacy and safety of dexzopiclone in the treatment of insomnia.Methods： Totally 140 patients with insomnia were randomly divided into two groups,and received dexzopiclone（3~6 mg,n=70） or lorazepam（1~2 mg,n=70） daily for 4 weeks.The scores of Asens sleep dysfunction rating（ASDR） and treatment emergent symptoms scale（TESS） were determined before and 1,2 and 4 weeks after treatment.Results： Compared with the baseline,sleeping quality was significantly improved in both groups with effective rates of 81.4%（dexzopiclone group） and 78.6%（lorazepam group）,respectively,4 weeks after treatment.There were no significant differences in the effective rates of two groups（P0.05）.However,dexzopiclone showed faster efficacy and lower incidence of adverse events than lorazepam（P0.01）.Conclusion： Dexzopiclone is effective and safe in the treatment of insomnia.