大口径毛细管气相色谱法测定丙帕他莫中3种有机溶剂的残留量

SIMULTANEOUS DETERMINATION OF 3 RESIDUAL ORGANIC SOLVENTS IN PROPACETAMOL BY LARGE DIAMETER CAPILLARY GC

目的:建立丙帕他莫中3种有机溶剂残留量的测定方法。方法:用大口径毛细管柱气相色谱法,以外标法计算残留溶剂的含量。结果:3种有机溶剂均完全分离,乙醇、丙酮、二氯甲烷的线性范围分别为100.72～1007.2μg/ml(r=0.9997)、103.86～1038.6μg/ml(r=0.9996)、12.94～129.4μg/ml(r=0.9997),平均回收率分别为99.9%、99.5%、100.8%,RSD分别为1.1%、1.3%、1.6%(n=5)。结论:所建方法灵敏、准确,可用于丙帕他莫中3种残留溶剂的同时测定。

To establish a method for determining 3 residual organic solvents in Propacetamol. Methods：Residual organic solvents were determined by large diameter capillary gas chromatography with external standardization. Results：3 compounds of residual organic solvents were separated completely.The standard curves of ethanol, acetone,and dichloromethane were linear in the ranges of 100.72-1007.2μg/ml （r=0.9997）, 103.86- 1038.6pog/ml （r=0.9996）,and 12.94-129.4μg/ml （r=0.9997）, respectively; and the average recoveries were 99.9%, 99.5% and 100.8% with the RSD of 1.1% ,1.3% and 1.6% （rt=5）, respectively. Conclusion：The method is sensitive, accurate and suitable for the determination of 3 residual organic solvents in pro^acetamol.