氟铝联合对体外人胚大脑神经细胞生长发育的影响

THE EFFECT OF ALUMINUM AND FLUORINE ON THE GROWTH AND DEVELOPMENT OF HUMAN EMBRYONIC CEREBRAL NEUROCYTES IN VITRO

目的：探讨氟铝联合对体外人胚大脑神经细胞生长发育的影响。方法：采用体外人胚大脑神经细胞，分为６ 组观察氟铝共存对其生长发育的影响。结果：大脑神经细胞的存活数高剂量铝组低于低剂量铝组和对照组，有显著性差别（Ｐ＜ ０．０５）。结论：高剂量铝组可抑制人胚大脑神经细胞的生长发育。

Objective:To study the toxic effect of aluminum and fluorine on Human embryonic cerebral neurocytes in vitro. Methods: The neurocytes were divided into six groups (control, low and high Al group, low Al and F, high Al and low F, high Al and F groups ), and the growth and development of neurocytes were observed . Results: Survival sum of cerebral neurocytes was lower in high Al group than that in low and control group . Conclusion: The results showed that the growth and development of neurocytes in high Al groups were inhibited. Fluorine was not effect on aluminum in this dose range .