替米沙坦治疗老年性高血压合并糖耐量低减(IGT)的疗效观察

目的探讨替米沙坦治疗老年性高血压合并IGT的临床效果。方法将临床诊断为高血压合并IGT老年患者共400例作为研究对象,年龄45～78岁,平均年龄(64.1±12.3)岁。随机分为试验组和对照组,试验组(N=200例)给予替米沙坦治疗,对照组(N=200例)给予苯磺酸氨氯地平治疗。随访2年,定期测量收缩压、心率、空腹和餐后2h血糖等。总结心肌梗死、脑卒中、心绞痛、心力衰竭、新发2型糖尿病的发生率。结果试验组SBP和FBG等指标与对照组相比统计学无显著性差异(P>0.05);HR和2hPBG显著低于对照组(P<0.05)。试验组心脑血管并发症发生率低于对照组(P<0.05)。结论替米沙坦治疗原发性高血压合并IGT患者,能在有效控制血压的同时更显著的控制餐后2h血糖,从而减少相关心脑血管事件的发生,改善患者生活质量。

Objective To explore the clinical effect of telmisartan used for elder patients with hypertension combined with IGT.Methods 400 cases of diagnostic patients as studied object were randomly divided into control group and experimental group.Control group was given therapy of amlodipine,and experimental group was given therapy of telmisartan.The time of follow-up visit was 2 years,the SBP,HR,2hPBG and FBG were monitored regularly,and myocardial infarction,cerebral apoplexy,angina,cardiac failure and T2D were summarized st the end.Results SBP and FBG in experimental group was better than control group,but no significant difference,HR and 2hPBG were significantly better than control group.The incidence rate and death rate of CCVD complications in experimental group was less than control group.Conclusion Telmisartan used for elder patients with hypertension combined with IGT,can control both of blood sugar and blood pressure,improve life quality of patients,so it is a considerable choose for therapy.