抗癌治疗新靶标——去整合素金属蛋白酶10

A new anti-cancer target： ADAM10

去整合素金属蛋白酶（ADAM）10基因是ADAM家族成员，其相应的细胞膜蛋白含有解聚素域和金属蛋白酶域，在细胞黏附、细胞融合、细胞迁移、膜蛋白脱落和分解等生物学行为中起作用。ADAM10蛋白在多种肿瘤中有过表达现象，能与数种黏附分子和癌症信号分子相互作用，促进肿瘤的侵袭和转移。以调控ADAM10的表达为靶目标，抑制肿瘤细胞的转移和侵袭，有望成为肿瘤治疗的新策略。

Gene ADAM10 （a disintegrin and metalloproteinase 10） is a member of ADAMs gene family. The corresponding membrane protein contains a disintegrin domain and a metalloproteinase domain. It is involved in various biological events such as cell adhesion, cell fusion, cell migration, and membrane protein shedding and proteolysis. ADAM10 protein is overexpressed in many tumors, which interacts with adhesion molecules and critical signaling molecules associated with cancer development and tumor progression, and promotes tumor invasion and metastasis. Regulating the expression of ADAM10 can inhibit tumor invasion and metastasis, which may become a new strategy for anticancer therapy.