矽肺与血液流变学关系的探讨

Studies on the Correlation Between Silicosis and Hemorrheology

目的探讨矽肺与血液流变学的关系。方法检测了 ７３例矽肺患者和 ６０例健康对照者血液流变学的各项指标。结果与对照组比较，患者组的红细胞压积（Ｈ）、４Ｓ^（－１）～２００Ｓ^（－１）切变率时的全血表观粘度（ηｂ）、血浆粘度（ηＰ）、红细胞电泳时间（ＥＥＴ）、血小板电泳时间（ＰＥＴ）平均值均显著升高（Ｐ＜０．００１）。直线回归和相关分析发现，上述各检测值除ηＰ外，余均随着患者病程的延长而逐步升高（Ｐ＜０．０５～０．０００１）。逐步回归分析发现，患者病情与 Ｈ、４Ｓ^（－１）和 ２００Ｓ^（－１）时的加及ＥＥＴ、ＰＥＴ值相关最为密切。结论矽肺患者的血液呈高凝和高粘滞状态，且随着病程延长而增高。

Objective To study the correlation between silicosis and hemorrheology. Methods The indexes of hemorrheology in 73 silicosis patients and 60 healthy subjects were measured. Results Compared with the control group,the average hematocrit (H), whole apparent viscosity (ηb) at 45^(-1)~ 200S^(-1) shear rates,plasma viscosity,erythrocyte electrophoresis time (EET) and platelet electrophoresis time (PET) values all were significantly increased (P<O.001);with lengthening of the courses of sili cosis patients,the indexes of silicosis patients increased (P<0.05-0.0001 ) Ithe correlation between H, ηb at 4S^(-1) ~ 200S^(-1),EET,PET and the courses of silicosis patients was clear. Conclusions The blood of silicosis patients was hypercoagulable,and the hypercoagulability increased as the courses of silicosis pa tients prolonged.