L-精氨酸和牛磺酸对同型半胱氨酸诱导平滑肌细胞增殖的抑制作用

The inhibitory effects of L-arginine and taurine on homocysteine-induced vascular smooth muscle cell proliferation

目的 观察Ｌ－精氨酸和牛磺酸对同型半胱氨酸（ＨＣＹ）诱导的血管平滑肌细胞（ＶＳＭＣ）增殖的影响。方法采用同位素技术测定ＶＳＭＣ３Ｈ－ＴｄＲ参入。结果ＨＣＹ可促进ＶＳＭＣ增殖。Ｌ－精氨酸及牛磺酸均可呈剂量依赖性抑制ＨＣＹ诱导的ＶＳＭＣ增殖，且合用Ｌ－精氨酸和牛磺酸的对ＶＳＭＣ增殖的抑制作用明显强于单纯应用Ｌ－精氨酸或牛磺酸组。结论Ｌ－精氨酸和牛磺酸均可抑制ＨＣＹ诱导的ＶＳＭＣ增殖。

Objective To investigate influence of L-arginine and taurine on homocysteine (HCY)induced vascular smooth muscle cell (VSMC) proliferation. Methods 3H-TdR incorporation was assayed with isotopic methed. Results HCY induced VSMC proliferation. L-arginine and taurine inhibited HCY-induced VSMC proliferation in a dose dependent manner. In addition, inhibitory effects of Larginine and taurine on VSMC proliferation was stronger significantly than L-arginine or taurine alone.Conclusion L-arginine and taurine inhibited HCY-induced VSMC proliferation.