摘要
采用 APAAP法和流式细胞仪研究 32例肺癌患者及 30例健康人外周血T细胞亚群及免疫细胞活性 ( NK- A)的变化。结果表明 :肺癌患者外周血 CD+3 、CD+4、CD+4/CD+8及 NK- A与正常人比较呈显著性降低 ( P <0 .0 5 ,P <0 .0 1 ) ;且肺癌伴癌转移者与未转移者上述各项指标亦有显著性差异 ( P <0 .0 5 )。说明肺癌患者存在细胞免疫功能降低 ;伴有癌转移的肺癌患者细胞免疫功能更低。提出积极调节肺癌患者细胞免疫功能 ,增强机体抗肿瘤能力十分重要。
T cell subjects and NK A in peripheral blood were measured by APAAP and Flow Cytometry in 32 patients with lung cancer.The results showed that the proportion of CD - 3,CD + 4 ratio of CD + 4/CD + 8 and NK A decreased significantly (P<0.05 or P<0.01) in comparison with normal control group.In addition, the proportion of CD + 3,CD + 4 ratio of CD + 4/CD + 8 and NK A in lung cancer with metastasis was significantly lower than that of lung cancer with nometastasis (P<0.05).It suggests that the cell immunie function in patients with lung cancer is decreased obviously.So it is important to improve the cell immunie function of patients with lung cancer.
出处
《西安医科大学学报》
CSCD
1999年第4期474-475,494,共3页
Journal of Xi'an Medical University(Chinese)
关键词
肺肿瘤
T细胞亚群
免疫细胞
lung tumor
T cell subjects
immunocyte
NK A
APAAP