229例成人甲型流感患者临床特征分析

Clinical features of 229 cases of adults influenza

目的分析229例确诊甲型流感（简称甲流）患者的临床特征。方法我院发热门诊中489例较典型流感样症状患者取鼻、咽拭子送流感网络实验室行流感病毒实时聚合酶链式反应检测。结果共检出甲流患者229例，其中非甲型H1N1流感患者178例，甲型H1N1流感患者51例，主要检出月份在2009年8—11月，患者从发病到就诊时间平均为（1．76±1．14）d。甲流患者中咽痛、咳嗽、咯痰、鼻塞、打喷嚏、流鼻涕、四肢酸痛发生率较高。但非甲型H1N1流感和甲型H1N1流感患者症状之间差异无统计学意义。甲流患者主要为青壮年人，但与非甲型H1N1流感患者相比，甲型H1N1流感患者的平均年龄较小。结论甲流患者较非甲流患者咽痛、咳嗽、咯痰、鼻塞、打喷嚏、流鼻涕、四肢酸痛发牛率高，给临床医师以提示，但无特异性。

Objective To analyze clinical features of 229 confirmed influenza A patients. Methods 489 cases had typical influenza-like symptoms, the nasopharyngeal swabs of the 489 cases were took and sent to CDC influenza network laboratory for influenza A real time polymerase chain reaction test. Results Among the 489 cases, there were 229 influenza A positive patients, 178 of 229 cases were normal influenza A positive patients, 51 of 229 cases were influenza A H1NI patients. The influenza A positive cases were mainly tested from August to December in 2009, the time from disease onset to visiting hospital was （1.76± 1.14） days. Compare with the influenza negative patients, symptoms such as sore throat, cough, expectoration, nasal congestion, sneezing, and runny nose were more frequently observed in influenza virus A positive patients. But the symptoms between normal influenza A and influenza A H1N1 had no significant difference. The influenza A positive patients were mainly young, but the influenza A H1N1 patients were younger than normal influenza A patients. Conclusions The symptoms of influenza A positive patients are more serious than those of influenza A negative patients.