妊高征患者胎盘组织细胞间粘附分子-1的表达

The expression of nitercelluler adhension molecule- 1 in Placental tissue with pregnancy induced hypertension

探讨细胞间粘附分子－１（ＩＣＡＭ－１）与妊高征发病的关系。方法：采用免疫组化ＳＰ法测定５０ 例妊高征患者和３０例正常孕妇胎盘组织内ＩＣＡＭ－１的表达。结果：与正常孕妇相比，①妊高征组胎盘血管内皮 ＩＣＡＭ－１的表达率及表达强度明显增高（Ｐ＜０．０１），且随着病情加重，血管内皮ＩＣＡＭ－１的表达增强（Ｐ＜０．０５）。 ②妊高征组胎盘绒毛合体滋养细胞ＩＣＡＭ－１的表达率及表达强度明显降低（Ｐ＜０．００５），且随着病情加重，绒毛 合体滋养细胞ＩＣＡＭ－１的表达减少（Ｐ＜０．０５）。结论：胎盘血管内皮及绒毛上皮ＩＣＡＭ－１的表达异常参与了妊 高征血管内皮损伤的病理生理过程，可能是妊高征发生发展过程中的一个重要环节。

: To study the relationship between intercellular adhension molecule-1(ICAM-1)and pregnancy -induced hypertension (PIH). Methods: 50 pregnant women with PIH and 30 normotensive pregnant women were studied in the present study. Expression of ICAM-1 in placental tissue was determined using immuno- histochemical staining. Results: Compared with the normotensive pregmamt women,① Expression of ICAM-1 in vascular endothelia in PIH group increased significantly(P < 0.01). The more severe, the more expansion of ICAM-1. ②Expression of ICAM-1 in vascular syncytiotro phoblast in PIH group decreased significantly(P<0.005)). The more severe, the less expression of ICAM-1. Conclusion: The abnormal expression of ICAM-1 in placental tissue in PIH may be involved in the pathophysiologic process of endothelial damage and development of PIH.