补中益气汤对小鼠非特异性免疫功能的影响

Effects of Buzhongyiqi Decoction on Nonspecific Immunologic Function in Mice

目的：研究补中益气汤对小鼠非特异性免疫功能影响。方法：以补中益气汤胃饲利血平致脾虚小鼠和正常小鼠。检测补中益气汤对脾虚及正常小鼠脾脏及胸腺指数、红细胞免疫功能、ＮＫ细胞活性、腹腔巨噬细胞分泌肿瘤坏死因子（ＴＮＦ）活性的影响。结果：脾虚小鼠经补中益气汤治疗后，免疫指标基本恢复正常，脾脏指数、胸腺指数、ＲＢＣ－Ｃ３ｂＲ花环率、ＲＢＣ－ＩＣ花环率、ＮＫ 细胞活性、ＴＮＦ活性分别恢复至（４．２８３±１．４７４） ｍ ｇ／ｇ、（２．２６２±０．４９７）％ 、（９．７８２±１．３６７）％ 、（８．７５３±１．４３６）％ 、（１７．３３２±６．０１７）％ 、（１４．９９７±５．７８３）％ 。结论：补中益气汤能明显恢复脾虚小鼠低下的非特异性免疫功能，而对正常小鼠无调节作用。

Objective:To study the immunologic regulating effects of Buzhongyiqi decoction on the spleen deficient mice model induced by reserpine and the normal mice.Methods:The spleen weight index,thymus weight index,RBC immunologic function (the rosette rate of RBV C3bR and RBC IC),activity of NK and TNF were measured.Results:After trentment immunogic function gain recovery and the above mentioned indexes reach respectively (4 283±1 474) mg/g、(2 262±0 497)%、(9 782±1 367)%、(8 753±1 436)%、(17 332±6 017)%、(14 997±5 783)%Conclusion: Buzhongyiqi decoction could restore the nonspecific immunologic function of spleen deficient mice, but had no regulating effect on immunlogic function of normal mice.