摘要
Multiresponsive magnetic microgels were synthesized using Fe3O4 nanomagnetic particles as seeds by precipitation polymerization. Thermogravimetric analysis (TGA) shows that the magnetic particles can be adequately encapsulated by resultant copolymer in reaction, and the amount of coating copolymer is about 78.9%. Magnetic measurement reveals that the composite particles have strong magnetic sensitivity and superparamagnetic property. The drug release as a function of temperature and pH shows that the release percentage at high temperature is significantly lower than low temperature, indicating a slow release behavior, and the release at various pH conditions does not carry out a prominent difference. This concerns the responsive degree of coating polymer on magnetic particles to pH solution.
Multiresponsive magnetic microgels were synthesized using Fe304 nanomagnetic particles as seeds by precipitation polymerization. Thermogravimetric analysis （TGA） shows that the magnetic particles can be adequately encapsulated by resultant copolymer in reaction, and the amount of coating copolymer is about 78.9 %. Magnetic measurement reveals that the composite particles have strong magnetic sensitivity and superparamagnetic property. The drug release as a function of temperature and pH shows that the release percentage at high temperature is significantly lower than low temperature, indicating a slow release behavior, and the release at various pH conditions does not carry out a prominent difference. This concerns the responsive degree of coating polymer on magnetic particles to pH solution.
基金
Development Funds of Shanghai Science and Technology, China (No. KJ2008-09)
