脑卒中急性期胃肠功能障碍患者血浆VIP水平变化的相关性研究被引量：3

Plasma Vasoactive Intestinal Peptide in Patients with Stroke Complicated with Gastrointestinal Dysfunction

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摘要目的了解脑卒中患者急性期血浆血管活性肠肽(VIP)水平的动态变化,探讨血管活性肠肽与脑卒中急性期继发胃肠功能障碍的相关性。方法应用放射免疫法检测192急性脑卒中患者入院24 h及入院1周时血浆血管活性肠肽水平,并与51名健康对照组比较。结果脑卒中急性期继发胃肠功能障碍患者VIP水平入院2 4 h(2 0 6.0 1±9.8 6)pg/mL及入院1周时(1 7 7.6 3±8.82)pg/mL血浆,较对照组(138.76±8.96)pg/mL显著偏高(P<0.01)。胃肠出血组入院1周时VIP水平与对照组相比未见统计学意义(P>0.05),而非胃肠出血组入院1周时VIP水平仍高于对照组。结论血浆高VIP水平与脑卒中急性期继发的胃肠功能障碍具有一定的相关性。不同的胃肠症状表现形式可能与VIP升降的幅度有关。 Objective To observe the dynamic changes of the plasma levels of vasoactive intestinal peptide（VIP） in patients（pts） with acute stroke complicated with gastrointestinal dysfunction.Methods The plasma level of VIP at 24 hours and one week after admission were measured by radioimmunoassay in 192 pts with acute stroke,and 51 subjects were as controls.Results At 24 hours and 1 week after admission,plasma VIP levels was significantly higher than that in normal control group（P0.01）.At 1 week after admission,there was no difference of VIP between the control group and gastrointestinal hemorrhage（P0.05）.There was difference between normal control group and non-gastrointestinal hemorrhage.Conclusion VIP level in pts with acute stroke complicated with gastrointestinal dysfunction was high.

作者唐明杨秀丽安朋朋李玲玲姜韫赟李倩

机构地区青岛市海慈医疗集团山东中医药大学

出处《中西医结合心脑血管病杂志》 2011年第7期815-817,共3页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

关键词脑卒中胃肠功能障碍血管活性肠肽 stroke gastrointestinal dysfunction vasoactive intestinal peptide

分类号 R743.3 [医药卫生—神经病学与精神病学] R255.2 [医药卫生—中医内科学]

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