脑钠肽在息性冠脉综合征中临床研究

Clinical research of plasma brain natriuretic- peptlde in acute coronary syndrome

目的：研充血浆脑钠肽（BNP）水平与严重程度不同的急性冠脉综合征（ACS）的联系．方法：采用免疫荧光法检测200例ACS患者起病24h内血浆BNP水平，其中不稳定心搜痛（UA）72例、非ST抬高性心肌梗死（NSTEMD58例、ST抬南性心肌梗死（STEMI）70例，对照组（CONTROL）：72例，健康中、老年人。研充BNP水平与不同ACS的联系。结果：CoNTROL组、UA组、NSTEMI组、STEMI组血浆BNP水平分别是62．86±6．72、143．06±12．87、279．42±28．81、617．54±69．56pg／ml，各组间比较具有显著差异（P〈0．05）．结论；血浆BNP水平变化与冠状动脉病变的严重程度相关，可作为ACS病情严重与否的评价标准．

Objective To research the relation between plasma brain natriuretic peptide （BNP） level and various kinds of acute coronary syndrome （ACS）. Methods Two hundred ACS patients were enrolled to detect plasma BNP level by immumofluorescence method within 24 hours after the onset, including 72 unstable angina pectoris （UA）, 58 non ST segment elevation myocardial infarction （NSTEMI） and 70 ST segment elevation myocardial infarc- tion （STEMI） cases, CONTROL, ？2 health mlddle--aged and aged people. The relation between BNP level and various kinds of ACS was analyzed. Re- sults Plasma level of BNP in CONTROL, UA, NSTEMI and STEMI groups was 62.86±6.72, 143.06±12.87, 279.42±28.81, 617.54：1：69.56pg/ml. There was a significant difference among all groups （P〈0.05）. Conclusion： The elevation of plasma BNP level is correlated with the severity of coronary artery lesion and could evaluate the ACS patients condition.