COPD骨骼肌萎缩患者临床特点及血清炎症因子水平研究

Research on clinical characteristics and inflammatory cytokines levels of patients with COPD combined with skeletal muscle atrophy

目的研究慢性阻塞性肺疾病(COPD)合并骨骼肌萎缩患者临床特点及血清炎症因子水平。方法比较健康组、COPD非萎缩组和COPD萎缩组临床特点和血清炎症因子水平并分析相关关系。结果 COPD萎缩组患者患COPD年限长、呼吸困难评分高、运动耐力下降,体重指数、脂肪质量、脂肪指数、去脂肪质量、去脂肪指数、肺功能均下降(均P<0.01),血清TNFa及IL-8升高(均P<0.01)。血清IL-8及TNFa与运动耐力,身体组成及肺功能负相关。结论 COPD骨骼肌萎缩患者患COPD年限长,运动耐力下降,肺功能下降,身体组成发生改变。血清炎症因子TNFa及IL-8升高与COPD骨骼肌萎缩相关。

Objective To study clinical characteristics and the levels of inflammatory cytokines in patients of chronic obstructive pulmonary disease（COPD） combined with skeletal muscle atrophy.Methods The general clinical features and serum inflammatory cytokines were compared among the control group,the non-atrophic COPD group and the atrophy COPD group and the measured of the correlations were analyzed.Results COPD combined with skeletal muscle atrophy suffered a long period,with high dyspnea and a decrease of exercise tolerance.Compared to those in the control group and non-atrophic COPD group,weight,body mass index,fat mass,fat mass index,fat free mass,fat free mass index and lung functions were all significantly decreased（P0.01,for each）,but serum IL-8 and TNFa significantly enhanced（P0.01,for each） in patients in the atrophy COPD group Serum IL-8 and TNFa negatively correlated with exercise tolerance,body compositions and lung functions.Conclusions Patients of COPD combined with skeletal muscle atrophy were suffered long years of COPD.Both of exercise tolerance and lung functions was reduced and body compositions were changed in these patient.The increased inflammatory serum cytokines TNFa and IL-8 are correlated with COPD combined with skeletal muscle atrophy.