昆明市延安医院2004～2007年病原菌分布、耐药状况及临床分析

Distribution and drug resistance of pathogens betweet 2004 and 2007 in Yan′an hospital of Kunming

目的了解病原菌的分布及耐药状况,为临床工作提供依据。方法对2004～2007年间分离的病原菌和药敏试验结果进行统计分析。结果共分离病原菌2066株,革兰阳性菌占24.25%,以凝固酶阴性葡萄球菌和金黄色葡萄球菌最多见;革兰阴性菌65.97%,以大肠埃希菌、铜绿假单胞菌为主;真菌9.78%,以白色念珠菌为主。大肠埃希菌、铜绿假单胞菌和金黄色葡萄球菌的感染比例逐年增加。耐甲氧西林葡萄球菌(MRS)和产超广谱β-内酰胺酶杆菌的检出率逐年增加,经同源性分析未发现MRS流行。分离的病原菌对大部分抗生素表现较高的耐药性。结论为了应对病原菌分布的变迁及其多耐药性,应加强对病原菌分布及耐药的监测、抗菌药物合理规范化使用以及严格的消毒管理工作。

Objective To expose the distribution and drug resistance of pathogens,and to provide the basis for clinical work.Methods The data of 2004~2007 of pathogens tests were analyzed.Results A total of 2066 pathogens were isolated,gram-positive bacteria accounted for 24.25%,the gram-negative bacteria was 65.97%,and the fungi was 9.78 %.Escherichia coli,Pseudomonas aeruginosa,Staphylococcus aureus infections and methicillin-resistant staphylococcus（MRS）,extended β-lactamase detection rate showed a yearly increase.The homology analysis showed no MRS epidemic in our hospital.The high resistance to antibiotics was detected among most isolated bacteria.Conclusions We should monitor pathogen distribution and drug resistance,closely use the antibiotics with caution and manage disinfection.