干扰素治疗慢性乙型肝炎的临床观察及护理

Clinical observation and nursing care of Interferon in treatment of chronic hepatitis B

目的探讨干扰素治疗慢性乙型肝炎(CHB)的临床效果及护理措施。方法 156例患者随机分为治疗组和对照组各78例。治疗组应用α-干扰素治疗,对照组应用常规治疗。观察2组HBV-DNA定量、血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、白蛋白(ALB)、胆碱酯酶(CHE)变化情况及不良反应发生情况。结果治疗组HBV-DNA、ALT、AST低于对照组,ALB、CHE高于对照组,差异有统计学意义(P<0.05)。治疗组患者有5例出现不良反应,经对症处理后均能缓解。对照组未见明显的药物不良反应。结论干扰素治疗CHB效果显著,临床应采取合理的护理措施。

Objective To investigate the effect and nursing methods of Interferon in treatment of chronic hepatitis B（CHB）.Methods 156 cases were randomly divided into treatment group and control group,76 cases of each.The treatment group was given interferon,while the control group was given conventional treatment.The quantitative of HBV-DNA,serum alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,albumin（ALB）,cholinesterase（CHE） and the incidence situation of adverse reactions of 2 groups were observed.Results The level of HBV-DNA,ALT,AST of the treatment group were less than those of the control group,respectively,while ALB,CHE were respectively higher than those of the control group,and all the differences were statistically significant（P0.05）.5 cases in the treatment group happened adverse reaction,who relieved after given symptomatic therapy.There was no obvious adveras drug reaction in the control group.Conclusion Interferon therapy in treatment of CHB is significant,and reasonable clinical care measures should be taken.