人脑胶质瘤组织中增殖细胞核抗原表达与病理分级和患者预后关系的研究

Relationship between PCNA expression with tumor pathological grade and prognosis in human brain glioma

目的研究人脑胶质细胞瘤组织中的增殖细胞核抗原(PCNA)表达及其与肿瘤临床病理学特征和患者预后的关系。方法应用免疫组化检测了25例人脑胶质瘤细胞中PCNA的表达水平,并分析人脑胶质瘤细胞中PCNA的表达水平与病理分级、患者生存时间的关系,取10例正常脑组织作对照。结果人脑胶质细胞瘤组织中PCNA阳性表达显著高于对照组,染色强弱与肿瘤的病理分级呈正相关,而与预后呈负相关。结论检测胶质瘤组织中PCNA表达能快速、准确地反映肿瘤细胞的增殖状态及评估患者预后,有望成为临床判定胶质瘤恶性程度及患者预后的重要指标。

Objective To study the relationship between proliferating cell nuclear antigen（PCNA）expression and the clinical pathological characteristic,as well as the prognosis of patients with glioma were observed.Methods The appearance of PCNA,pathological grade and prognosis was analysised in 25 biopsy-specimens of human brain astrocytoglioma and 10 normal brain tissues were used as normal group by immunohistochemical method.Results The result showed that the expression of PCNA in glioma tissue was significantly stronger than that in the normal tissue,while staining of tumor tissues was positively correlated with tumor grade.But there was negatively connection between staining of tumor tissues and outcome of patients with tumors.Conclusion It suggests that the detection of PCNA expression in glioma tissues can show the proliferating station of tumor cells and assess patient＇s prognosis rapidly and precisely.The appearance of PCNA can be used as an important index of assessing the malignant degree and the prognosis of human glioma.