期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Axl及其配体蛋白Gas6在急性白血病中的表达及其与诱导缓解治疗疗效之间的关系 被引量：2

原文传递
导出
摘要 Axl属于受体酪氨酸激酶（receptortyrosinekinases，RTK）家族成员，在基因转录调节中起重要作用，参与对细胞存活、增殖、黏附、迁移及抗凋亡的调节。Gas6为Axl的生物配体，已经发现Gas6-Axl与多种肿瘤细胞的增殖、存活、
作者 周芳慧 樊娟 韩立平 王欣 王蕊 李颖
机构地区 山东大学附属省立医院血液科
出处 《中华血液学杂志》 CAS CSCD 北大核心 2011年第7期479-481,共3页 Chinese Journal of Hematology
基金 山东省科技发展计划基金（2007GG30002013）
关键词 GAS6 生物配体 缓解治疗疗效 急性白血病 基因转录调节 受体酪氨酸激酶 蛋白 细胞存活
分类号 R733.7 [医药卫生—肿瘤]
  • 相关文献

参考文献9

  • 1Rescigno J, Mansukhani A, Basilico C. A putative receptor tyro- sine kinase with unique structural topology. Oncogene, 1991,6: 1909-1913.
  • 2Varnum BC, Young C, Elliott G, et al. Axl receptor tyrosine ki- nase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. Nature,1995,373:623-626.
  • 3Sasaki T, Knyazev PG, Clout NJ,et al. Structural basis for Gas6- Axl signalling. EMBO J ,2006,25:80-87.
  • 4Lay JD, Hong CC, Huang JS, et al. Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL. Cancer Res, 2007,67:3878-3887.
  • 5Sawabu T, Seno H, Kawashima T, et al. Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway. Mol Carcinog,2007,46 : 155-164.
  • 6Hong CC, Lay JD, Huang JS, et al. Receptor tyrosine kinase AXLis induced by chemotherapy drugs and overexpression of AXL con- fers drug resistance in acute mueloid leukemia. Cancer Lett,2008, 268 : 314-324.
  • 7Wu YM, Robinson DR, Kung HJ. Singal pathways in up-regulation of chemokines by tyrosinekinase MER/NYK in prostate cancer cells. Cancer Res, 2004,64:7311-7320.
  • 8Sainaghi PP, Castello L, Bergamasco L, et al. Gas6 induces prolif- eration in prostate carcinoma cell lines experssing the Axl receptor. J Cell Physio1,2005,204 : 36-44.
  • 9Neubauer A, Burchert A, Maiwald C, et al. Recent progress on the role of Axl, a receptor tyrosine kinase, inmalignant transforma- tion of myeloid leukemias. Leuk Lymphoma, 1997,25:91-96.

同被引文献71

  • 1Kaatsch P. Epidemiology of childhoodcancer [J], Cancer treatment reviews,2010, 36(4):277-285.
  • 2Branchford BR, Brzezinski C, SatherS, et al. Novel Small MoleculeInhibitors Of The Gas6/TAM SignalingPathway Inhibit Platelet Aggregation InVitro and Protect Mice From Arterialand Venous Thrombosis In Vivo [J].Blood, 2013, 122(21):2296-2296.
  • 3Tang H,Chen S,Wang H,et al. TAMreceptors and the regulation oferythropoiesis in mice [J].Haematologica,2009, 94 (3) : 326 -334.
  • 4Wang H,Cnhen S , Chen Y,et aL Therole of Tyro 3 subfamily receptors in theregulation of hemostasis and megakary-ocytopoiesis[j]. Haematologica, 2007,92(5):643-650.
  • 5Cummings CT, DeRyckere D, EarpHS, et al. Molecular pathways :MERTK signaling in cancer [J]. ClinCancer Res, 2013, 19 (19):5275-5280.
  • 6HongCC,Lay JD, Huang JS,et al.Receptor tyrosine kinase AXL isinduced by chemotherapy drugs andoverexpression of AXL confers drugresistance in acute myeloid leukemia[J]. Cancer Letters, 2008,268(2):314-324.
  • 7Ghosh AK, Secreto C, Boy sen J, et al.The novel receptor tyrosine kinase Axlis constitutively active in B-cell chroniclymphocytic leukemia and acts as adocking site of nonreceptor kinases:implications for therapy [J]. Blood,2011, 117(6):1928-1937.
  • 8Kubo T, Kuroda Y, Shimizu H,et al.Resequencing and copy number analysisof the Human yrosine kinase gene familyin poorly differentiated gastric cancer[J]. Carcinogenesis, 2009,30(11):1857-1864.
  • 9Breton CV,Salam MT,Gilliland FD.Heritability and role for the environmentin DNA methylation in AXL receptortyrosine kinase [J]. Epigenetics,2011,6(7):895-898.
  • 10Avilla E, Guarino V,Visciano C, etal. Activation of TYR03/AXL tyrosinekinase receptors in thyroid cancer [J].Cancer Res, 2011,71(5) : 1792-1804.

引证文献2

二级引证文献4

中华血液学杂志
2011年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部