北五味子对小鼠学习记忆及脑SOD和MDA的影响

Effect of FRUCTUS SCHISAN DRAE CHINENSIS on Learning and Memory of Mice and Content of SOD and MDA in Brain of Mice

[目的]了解北五味子醇提取物对小鼠学习记忆能力及脑组织中超氧化物歧化酶(SOD)和丙二醛(MDA)含量的影响。[方法]将健康昆明小鼠随机分为对照组和北五味子醇提取物低、中、高剂量组,连续灌胃28d,通过Morris水迷宫试验检测小鼠学习记忆能力的变化;并测定小鼠脑组织SOD、MDA含量。[结果]北五味子提取物灌胃后经Morris水迷宫定位航行试验检测发现,第7、14、21天各组小鼠逃避潜伏期无显著差异(P>0.05),第28天高剂量组小鼠逃避潜伏期较对照组显著延长(P<0.05)。各组小鼠脑组织SOD活力较对照组出现不同程度降低(P<0.05),MDA含量无显著差异(P>0.05)。[结论]北五味子提取物对小鼠学习记忆能力可能没有明显影响,但可能影响脑组织中SOD含量。

[Objective]To study effect of FRUCTUS SCHISAN DRAE CHINENSIS on the learning and memory,and Content of superoxide dismutase（SOD） and malondialdehyde（MDA） in brain of mouse.[Method]Mice were randomly divided into four groups like control group and low,meddle and high dose of alcohol ederact of groups,intragastric administration for 28 days.The changes of learning and memory ability in mice were detected by Morris water maze,and content of SOD and MDA in brain of mice were determined.[Result]Seven,fourteen and twenty-one days after given medicine,mice in each group were not significant different in incubation to escape（P 〉 0.05）.Given medicine for 28 days,mice in high dose group was significantly longer in incubation to escape compared to CK（P 〈 0.05）.In comparison with CK,mice in each medicine group was lower in SOD activity（P 〈 0.05） and content of MDA did not vary significantly（P 〉 0.05）.[Conclusion]FRUCTUS SCHISAN DRAE CHINENSIS extracts might not possess distinct influence on learning and memory of mice,but might show effect on content of SOD in brain.