摘要
目的:评价多西紫杉醇联合FOLFOX方案治疗晚期胃癌的疗效及不良反应。方法:21例晚期胃癌患者,初治11例,复治10例,使用多西紫杉醇35mg/m2,静滴1h,d1、d8;奥沙利铂50mg/m2,静滴2h,d1、d8;亚叶酸钙200mg/m2,静滴2h,d1,d2,d8,d9,氟尿嘧啶300mg/m2,静推(cF后进行)d1,d2;d8,d9,氟尿嘧啶500mg/m2,持续输注48h(氟尿嘧啶静推后进行)d1-2;d8-9,以上化疗每3周重复。所有病人接受2周期及以上化疗,平均3.2周期。结果:有效率为57.1%(12/21),初治72.7%(8/11),复治30%(3/10)。初治组中3例做二期手术治疗。主要不良反应为周围神经毒性,骨髓抑制,脱发,恶心,呕吐和腹泻,没有严重化疗并发症发生。结论:多西紫杉醇联合FOLFOX方案治疗晚期胃癌是有效的方案,临床上可有选择地应用。
Objective： To evaluate the efficacy and toxicity of weekly dose of doeetaxel plus oxaliplatin with LV and 5 - Fu （FOLFOX） regimen in the treatment of advanced gastric carcinoma. Methods：Totally 21 advanced gastric carcinoma patients, including 11 cases previously untreated and 10 eases previously treated were enrolled in this study and treated with the following regimen, administered every 21 days, docetaxe135mg/m^2 by ivgtt I h on dl, d8, oxaliplatin 50mg/m^2 by ivgtt 2h on d1, d8, CF 200mg/m^2 by ivgtt 2h dl ,d2 ,d8, d9,5 - FU 300 mg/m^2 by iv blous dl, d2 d8, d9,5 - FU 500 mg/m^2. by 48h eiv d1 -2 ,d8 -9. All the patients received over two cycles of ehemotherapy, median 3.2 cycles. Results ： The overall response rate （ CR ＋ PR） was 57.1% （ 11/21 ）. The response rate of the patients previously untreat- ed was 72.7% （8/11） ,the the response rate of patients previously treated was 30% （3/10）. The major toxic side effect were perineural toxici,myelosuppression,lopeia, mausea, vomiting and mueositis, No serious complication appeared. After chemotherapy, three patients previously untreated received operaton. Conclusion： The weekly dose of docetaxel plus FOLFOX regimen is a practical and effective chemotherapy for advanced gastric carcinoma,the value needs further dinieal test and can be used selectively.
出处
《医学信息（中旬刊）》
2011年第7期2880-2881,共2页
Medical Information Operations Sciences Fascicule
