舒血宁对急性脑出血患者血中炎症细胞因子水平的影响研究

Shuxuening injection on the levels of inflammatory cytokines with acute cerebral hemorrhage

目的:观察舒血宁注射液对急性脑出血患者外周血中炎症细胞因子水平的影响。方法:将90例急性脑出血患者随机分为舒血宁治疗组和胞二磷胆碱对照组,每组各45例。采用放射免疫法测定各组患者治疗前后血中肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平,并与40例正常人进行对照。结果:两组急性脑出血患者治疗前血浆TNF-α和IL-6水平均明显高于正常对照组(P<0.05)。治疗14d后,两组患者血浆TNF-α、IL-6水平均明显下降(P<0.05),治疗组下降程度明显高于对照组(P<0.01)。结论:舒血宁注射液能显著抑制炎症细胞因子的释放,降低细胞因子的水平,促进脑出血患者的神经康复。

Objective：To observe the Shuxuening injection on peripheral blood of patients with acute intraeerehral hemorrhage levels of imqanunatory eytokines. Methods ：90 cases of acute cerebral hemorrhage were randomly divided into treatment group and Shuxuening eiticoline group ,45 patients in each group. Measured by radioinmlunoassay of blood before and after treatment in each group of tumor necrosis factor-α （TNF- α） and interleukin -6 （IL-6） levels and were compared with 40 normal subjects. Results：Both groups of patients with acute cerebral hemorrhage before treatment plasma TNF - α and IL -6 levels were signillcandy higher than the control group （ P 〈0. 05 ）. 14d after treatment, both groups of plasma TNF - α, IL - 6 levels were significantly decreased （ P 〈 0. 05 ） , decreased level of treatment group was significantly higher （ P 〈 0.01 ）. Conclusion ： Shuxuening injection could significantly inhibit the release of inflammatory cytokines,lower levels of cytokines, and promote neurological rehabilitation in patients with cerebral hemorrhage.