218例艾滋病并高血压患者合理应用降压药物治疗效果分析

To analysis the clinical curative effect about treating 218 patients with AIDS and high blood pressure through regulated using antihypertensive drugs

目的:探讨艾滋病并高血压患者应用降压药物情况及治疗方案,评价其治疗效果及安全性。方法:回顾性分析218例艾滋病并高血压患者合理应用降压药物及治疗临床效果、药物不良反应等临床资料。结果:我院218例艾滋病并高血压患者使用降压药物总频数372例次,总不良反应发生率5.65%;单联降压治疗组77例(35.3%),降压治疗总有效率36.36%,不良反应发生率14.29%;联合治疗141例(64.7%),降压治疗总有效率58.16%,不良反应发生率5.67%;联合治疗组总有效率和不良反应发生率与单联治疗组相比较,两组差异均有显著性(P<0.05)。结论:合理使用降压药物可以降低艾滋病并高血压患者不良反应发生率,治疗安全性高。艾滋病并高血压患者降压治疗达标率低,但联合药物降压较单联药物降压总有效率更高,药物不良反应发生率更低,安全性更高。

Objective：To explore the situation of patients with AIDS and high blood pressure applieate using antihypertensive drugs and individualized antihyper- tensive methods, and evaluate the treatment efficacy and safety. Methods：To analysis retrospeetly the clinical data about the clinical curative effect and adverse drug reactions so on for 218 patients with AIDS and high blood pressure,who use antihypertensive drugs reasonably and use individualized treatment. Results：At our hospital, in the 218 patients with AIDS and high blood pressure,who through regulated using antihypertensive drugs,the total frequency of drug use is 372 times,the total incidence of adverse reaction is 5.65 percent;the separate league antihypertensive treatment group is 77 patients （35.3 percent） , the total efficiency of antihypertensive therapy is 36.36 percent, the incidence of adverse reaction is 14.29% ;the combination therapy is 141 patients（64.7 percent） , the total efficiency of antihypertensive therapy is 58.16 percent, the incidence of adverse reaction is 5.67 percent; Compare the combined treatment group with separate league treatment group, the differences are significant in the total efficiency and total incidence of adverse reaction （P 〈 0. 05 ）. Conclusion：To use antihypertensive drugs correctly and reasonably can reduce the incidence of adverse reaction for patients with AIDS and high blood pressure, and the reatrnent security is high. The standard rate of antihypertensive therapy for patients with AIDS and high blood pressure is low, but compare with the incidence of separate league treatment drug, the antihypertensive overall efficiency of the combined treatment drugs is higher, the incidence of adverse reaction of the combined treatment drugs is lower,and the reatment security of the combined treatment drugs is higher.