NAHC方案治疗老年单纯收缩期高血压的疗效观察

Efficacy of NAHC Program in Elderly Patients with Isolated Systolic Hypertension

目的:观察小剂量NAHC个体化治疗方案对老年单纯收缩期高血压的临床疗效。方法:入选老年单纯收缩期高血压患者108例,采用小剂量NAHC个体化治疗方案,疗程12周,每2周随访一次,观察收缩压、舒张压、心率、显效率、总有效率及不良反应。结果:治疗12周后,患者显效率为88.9%,总有效率为96.3%,不良反应发生率仅0.9%,全部患者均按治疗方案服药。与治疗前相比,患者收缩压从170.8±13.9mmHg下降到130.4±4.2mmHg(P<0.05),舒张压从72.6±8.2mmHg下降到70.5±7.8mmHg(P>0.05),心率从78.6±6.3次/分下降到75.1±6.2次/分(P<0.05),血糖、血脂、血尿酸及血钾水平差异无统计学意义(P>0.05)。结论:小剂量NAHC个体化治疗方案能有效降低老年单纯收缩期高血压患者的血压,耐受性良好,不良反应小。

Objective：To observe clinical efficacy of small dose of NAHC individualized treatment program in elderly patients with isolated systolic hypertension. Methods： Selected 108 cases of elderly patients with isolated systolic hypertension were treated by small dose of NAHC individualized treatment program. Course of treatment was 12 weeks. All patients were followed up once every 2 weeks and systolic blood pressure, diastolic blood pressure, heart rate, the rate of significant effleiency, the total effective rate and adverse reaction were observed. Results：After 12 weeks, the rate of significant efficiency was 88.9%, the total effective rate was 96.3% , the rate of adverse reaction was only 0.9%, and all patients took medicine according to treatment protocols. Compared with pretherapy, systolic blood pressure decreased from 170.8 ± 13.9mmHg to 130.4 ± 4.2mmHg（ P 〈 0. 05 ）, diastolic blood pressure decreased from 72.6 ± 8.2mmHg to 70.5 ± 7.8 mmHg（ P 〉 0. 05 ）, heart rate decreased from 78.6 ± 6.3 bpm to 75.1 ± 6.2bpm （ P 〈 0.05 ） , and blood glucose, blood lipids, blood uric acid and blood kalium ion were no significant difference （ P 〉 0.05 ）. Conclusion ： Small dose of NAHC individualized treatment program can effectively decrease the blood pressure of elderly patients with isolated systolic hypertension, be well tolerated and has little adverse reaction.