摘要
对正常血压伴微量白蛋白尿（MAU）的NIDDM患者进行随机双盲、安慰剂对照的前瞻性研究，以观察培哚普利（perindopril）的肾脏保护作用。方法58例NIDDM患者随机分为A组（培哚音利，4mg／d）、B组（安慰剂组），治疗14个月。结果培哚普利治疗后A组收缩压、舒张压、平均动脉压明显下降（P=0．05，0．05，0．01）。MAU有所下降，但无显著性差异（P=0．06）。结论为期1年的小剂量培跌普利治疗有可能降低正常血压NIDDM患者的微量白蛋白尿。
Objective To evaluate the effect of perindopril on urinary albumin excretion(UAE) in a prospective randomised double-blind trial in normotensive diabetic patients with microalbuminuria (MAU). Methods 58 patients with UAE from 20 t0 200 μg/min as MAU group were divided into perindopril (A, perindopril 4mg/d) and placebo group (B). Results The data showed that diastolic blood pressure and mean blood pressure in A group after 14 months treatment were significantly decreased at the end of study (P=0. 05, P=0. 01, respectively). UAE levels were decreased in A group (P=0.06). Conclusion This results showed that perindopril in a dosage of 4 mg daily during one year treatment could decrease diastolic blood pressure, and had benefit effect on MAU in normotensive NIDDM patients.
出处
《中国糖尿病杂志》
CAS
CSCD
1999年第6期327-329,共3页
Chinese Journal of Diabetes
基金
全军九五科技攻关课题
关键词
糖尿病
白蛋白尿
肾病变
预防
ACEI
Non-insulin dependent diabetes
Microalbuminuria
Perindopril
