可溶性主要组织相容性复合体Ⅰ类链相关蛋白A表达水平与妇科恶性肿瘤的相关性

Relationship between Expression Level of Soluble Major Histocompatibility Complex ClassⅠChain-related Protein A and Gynecologic Malignant Tumors

目的分析血清中可溶性主要组织相容性复合体Ⅰ类链相关蛋白A(Soluble major histocompatibility complexclass I chain-related protein A,sMICA)与妇科恶性肿瘤的相关性。方法应用ELISA法检测59例确诊为妇科恶性肿瘤患者和98名健康对照者血清中sMICA的水平,应用ROC曲线对检测结果进行分析与评价。结果病例组患者血清中sMICA平均水平[(1.04±1.33)ng/ml]明显高于健康对照组[(0.29±0.30)ng/ml)],且差异有统计学意义(P<0.000 1)。ROC曲线下面积为0.816,sMICA的临床诊断界点为0.302 ng/ml。结论血清中sMICA水平与妇科恶性肿瘤的发生密切相关,有望作为临床妇科肿瘤诊断的一种新型肿瘤标志物。

Objective To analyze the relationship between expression level of soluble major histocompatibility complex class Ⅰ chain-related protein A（sMICA） and gynecologic malignant tumors.Methods The sMICA levels in sera of 59 patients with confirmed gynecologic malignant tumors and 98 healthy women were determined by ELISA,and the results were analyzed and evaluated by ROC curve.Results The sMICA levels in sera of patients with gynecologic malignant tumors [（1.04 ± 1.33） ng/ml] were significantly higher than those of healthy women[（0.29 ± 0.30） ng/ml）,P 〈 0.000 1].The area under ROC curve was 0.816,and the cut-off value of sMICA for clinical diagnosis was 0.302 ng/ml.Conclusion The sMICA level in sera was closely related to the onset of gynecologic malignant tumors,which might be used as a novel tumor maker for clinical diagnosis.