核转录因子NF-κB及其抑制剂的研究进展

Progress in Research on NF-κB and Its Inhibitor

核转录因子κB（Nuclear factor-kappa B,NF-κB）存在于多种组织细胞中,具有广泛的生物学活性,参与多种生理、病理过程中的基因调控。通过抑制以NF-κB为核心的信号转导途径,可能为防治某些疾病开辟新途径。本文就NF-κB的生物学特性、激活及其抑制剂的研究进展作一综述。

Nuclear factor-kappa B（NF-κB） exists in various tissues and cells and has broad biological activities,which involves in gene regulation in various physiological and pathological courses.The inhibition of NF-κB signaling pathway might provide a novel route to the prevention and treatment of some diseases.This paper reviews the progress in research on biological character,activation and inhibitor of NF-κB.