食管癌螺旋CT灌注成像与肿瘤血管生成的相关性研究

Correlation Study between Spiral CT Perfusion Imaging and Angiogenesis in Esophageal Carcinoma

目的探讨食管癌螺旋CT灌注成像与肿瘤血管生成的相关性。资料与方法对50例食管癌患者行多排螺旋CT灌注扫描,分析食管癌CT灌注成像参数血容量(BV)、血流量(BF)、平均通过时间(MTT)、表面通透性(PS)与微血管密度(MVD)及血管内皮生长因子(VEGF)表达之间的关系。结果 50例食管癌中,VEGF阳性表达率为62%(31/50),阴性表达率为38%(19/50),MVD值在两组间的差异具有统计学意义(P<0.05);BF值与MVD呈正相关(P<0.05),BV及PS值与MVD呈显著性正相关(P<0.01),MTT值与MVD无相关性(P>0.05);PS值与VEGF表达呈正相关(P<0.05),BF、BV及MTT与VEGF表达无相关性(P>0.05)。结论食管癌CT灌注成像能够在一定程度上反映活体的肿瘤血管生成状况。

Objective To evaluate the correlation between spiral CT perfusion imaging and angiogenesis in esophageal carcinoma.Materials and Methods Multi-detector spiral CT perfusion scan was performed in 50 patients with esophageal carcinoma.The relationship of the CT perfusion imaging parameters,including blood volume（BV）,blood flow（BF）,mean transit time（MTT）,and permeability surface（PS）,with MVD and expressions of VEGF were analyzed.Results In 50 cases,the VEGF positive expression rate was 62%（31/50）,and the negative expression rate was 38%（19/50）.The mean MVD of VEGF-positive group were significantly higher than those of negative group（P0.05）.CT perfusion parameter BF values and MVD count were positively correlated（P0.05）.The correlation between BV,PS values and MVD count were more significantly positive correlated（P0.01）.There was no statistical correlation between MTT values and MVD count（P0.05）.The PS value and VEGF expression were positively correlated（P0.05）.There was no statistical correlation between BF,BV,MTT values and VEGF expression（P0.05）.Conclusion CT perfusion parameters can reflect not only the angiogenesis of esophageal carcinoma of the MVD,but also the expression of VEGF,indicating that CT perfusion parameters can be used as an assessment of tumor angiogenesis in vivo.