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以氯离子通道蝎毒素为靶分子的分子影像研究进展 被引量：1

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摘要 分子影像学是利用影像学手段研究在体条件下细胞内的正常或病理状态分子过程,在分子或细胞水平反映生物体生理、病理变化,为疾病过程在体监测、基因治疗在体示踪、药物在体疗效评测和功能分子在体活动规律研究提供新的技术,具有无创、实时、在体、特异、精细显像等优点[1]。
作者 昌倩 肖恩华
机构地区 中南大学湘雅二医院放射科
出处 《临床放射学杂志》 CSCD 北大核心 2011年第7期1071-1073,共3页 Journal of Clinical Radiology
关键词 分子影像学 氯离子通道 靶分子 蝎毒素 在体监测 分子过程 病理状态 细胞水平
分类号 R445 [医药卫生—影像医学与核医学]
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参考文献21

  • 1Weissleder R, Pitter MJ. Imaging in the era of molecularoncology. Nature,2008,452:580.
  • 2赵灿国,孔天翰.蝎毒素调控离子通道的研究新进展[J].河南职工医学院学报,2005,17(1):61-64. 被引量：5
  • 3许均华,吴英亮,罗锋,蒋达和.蝎氯毒素结构、功能与应用研究[J].氨基酸和生物资源,2005,27(4):13-16. 被引量：4
  • 4DeBin JA, Maggio JE, Strichartz GR. Purification and characterization of chlorotoxin, a chliride channel ligand from the venom of the scorp ion. Am J Physiol, 1993,264:361.
  • 5Ullrich N, Bordey A, Gillespie GY, et at Expression of voltage-activated chloride currents in acute slices of human gliomas. Neuroscience, 1998,83 : 1161.
  • 6Dalton S, Gerzanich V, Chen M, et al Chlorotoxin-Sensitive Ca2 + Activated C1- Channel in Type R2 Reactive Astrocytes From Adult Rat Brain. Glia,2003,42:325.
  • 7Fu Y J, Yin LT, Liang AH, et al. Therapeutic potential of chlorotoxinlike neurotoxin from the Chinese scorpion for human gliomas. Neurosci Lett ,2007,412:62.
  • 8Sontheimer H. An Unexpected Role for Ion Channels in Brain Tumor Metastasis Rinl Med (Maywnnd),2008,233:779.
  • 9Veiseh M, Gabikian P, Bahrami SB, et al Tumor Paint : A Chlorotoxin : CyS. 5 Bioconjugate for Intraoperative Visualization of Cancer Foci. Cancer Research ,2007,67:6882.
  • 10Soroceanu L, Manning TJ Jr, Sontheimer H. Modulation of glioma cell migration and invasion using CI( - ) and K( + ) ion channel blockers. J Neurosci, 1999,19:5942.

二级参考文献21

  • 1杨锐,彭方,刘辉,曹志贱,李文鑫,毛歆,蒋达和.东亚钳蝎氯毒素BmKCT的表达和功能鉴定(英文)[J].中国生物化学与分子生物学报,2005,21(1):19-23. 被引量：10
  • 201amendi-Portugal T,Garcia BI,Lopez-Gonzlez I,Van Der Walt J,et al.Two new scorpion toxins that target voltage-gated Ca2+ abd Na+ channels[J].Biochem Biophys Res Commun,2002,299(4):562～568
  • 3Inceoglu AB,Hayashida Y,Lango J,et al.A single charged surface residue modifies the activity of ikitoxin,abeta-type Na+ channel toxin from Parabuthus transvalicus[J].Eur J Biochem,2002,269(22):5 369～5 376
  • 4Zeng XC,Wang SX,Zhu Y,et al.Identification and functional characterization of novel scorpion venom peptides with no disulfide bridge from Buthus martensi Korsch[J].Peptides.2004,25(2):143～150
  • 5Gao YD,Garcia ML.Interaction of gitoxin2,charybdotoxin,and iberiotoxin with potassium channels:selectivity between voltage-gated and Maxi-K channels[J].Proteins,2003,52(2):146～154
  • 6Jouirou B,Mosbah A,Visan V,Grissmer S,et al.Cobatoxin 1 from Centruroides noxius scorpion venom:chemical synthesis,three-dimensional structure in solution,pharmacology and docking on K+ channels[J].Biochem J,2004,377(Pt 1):37～49
  • 7Rodrigues AR,Arantes EC,Monje F,et al.Tityustoxin-K(alpha) blockade of the voltage-gated potassium channel Kv1.3[J].Br J Pharmacol1,2003,139(6):1 180～1 186
  • 8Guijarro JI,M Barek S,Gomez-Lagunas F,et al.Solution structure of Pi4,a short four-disulfide-bridged scorpion toxin specific of potassium channels[J].Protein Sci,2003,12(9):1 844～1 854
  • 9Dhawan R,Varshney A,Mathew MK,et al.a new inhibitor of the Kv1.1 potassium channel purified from Indian scorpion Buthus tamulus[J].FEBS Lett,2003,539(1～3):7～13
  • 10Huys I,Waelkens E,Tytgat J.Structure-function study of a chlorotoxin-chimer and its activity on Kv1.3 channels[J].J Chromatiogr B Analyt Technol Biomed Life Sci,2004,803(1):67～73

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同被引文献29

  • 1Morell A G, Irvine R A, Sternlieb I, et al. Physical and chemical studies on cerulopLasmin. V. metabolic studies on sialie acid free ceruloplasmininvivo[J].J BiolChem, 1968, 243(1):155-159.
  • 2Weissleder R. Molecular imaging: exploring the next frontier [J]. Radiology, 1999, 212(3):609--614.
  • 3Oghabian M A, Farahbakhsh N M. Potential use of nanoparticle based contrast agents in MRI: a molecular imaging perspective [J]. J Biomed Nanotechnol, 2010, 6(3):203-213.
  • 4Cai W, Niu G, Chen X. Imaging of integrins as biomarkers for tumor angiogenesis[J]. Curr Pharm Des, 2008, 14 (28) : 2943-- 2973.
  • 5Carrasquillo J A, Chen C C. Molecular imaging of neuroendocrine tumors[J]. Semin Oncol, 2010, 37(6) :662-679.
  • 6Lecchi M, Ottobrini L, Martelli C, et al. Instrumentation and probes for molecular and cellular imaging [J]. Q J Nucl Med Mol Imaging, 2007, 51(2) :111--126.
  • 7Galli G, Maini C L, Orlando P, et al. A radiopharmaceutical for the study of the liver:99m Te-DTPA-asialo-orosomucoid I: radio chemical and animal distribution studies[J]. Nucl Med Allied Sci, 1988,32(2) :110-- 116.
  • 8Sugahara K, Togashi H, Takahashi K, et al. Separate analysis of asialoglycoprotein receptors in the right and left hepatic lobes using 99mTc GSA SPECT[J1. Hepatology, 2003,38 (2) : 1401-1409.
  • 9Shuke N, Okizaki A, Kino S, et al. Functional mapping of re- gional liver asialoglycoprotein receptor amount from single blood sample and SPECT [J]. J Nucl Med,2003,44(3) :475--482.
  • 10Yoshida M, Shiraishi S, Sakaguchi F, et al. Fused 99m Tc-GSA SPECT/CT imaging for the preoperative evaluation of postoper- ative liver function: can the liver uptake index predict postopera- tive hepatic functional reserve? [J]. Jpn J Radiol, 2012,30 (3) : 255--262.

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临床放射学杂志
2011年 第7期

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